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Scientific paper - Original scientific paper
In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro
Emergency Medicine International, 2020 (2020); 6805354. https://doi.org/10.1155/2020/6805354
Ložić, Marin; Stambolija, Vasilije; Krezić, Ivan; Dugandžić, Aleksandra; Živanović-Posilović, Gordana; Gojković, Slaven; Kovačević, Josip; Vrdoljak, Luka; Mirković, Ivan; Kokot, Antonio; Petrović, Andreja; Horvat Pavlov, Katarina; Drmić, Domagoj; Šuran, Jelena; Boban Blagaić, Alenka; Seiwerth, Sven; Sikirić, Predrag More authors...

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Ložić, M., Stambolija, V., Krezić, I., Dugandžić, A., Živanović Posilović, G., Gojković, S. ... Sikirić, P. (2020). In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International, 2020.. doi: 10.1155/2020/6805354

Ložić, Marin, et al. "In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro." Emergency Medicine International, vol. 2020, 2020. https://doi.org/10.1155/2020/6805354

Ložić, Marin, Vasilije Stambolija, Ivan Krezić, Aleksandra Dugandžić, Gordana Živanović Posilović, Slaven Gojković, Josip Kovačević, et al. "In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro." Emergency Medicine International 2020 (2020). https://doi.org/10.1155/2020/6805354

Ložić, M., et al. (2020) 'In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro', Emergency Medicine International, 2020. doi: 10.1155/2020/6805354

Ložić M, Stambolija V, Krezić I, Dugandžić A, Živanović Posilović G, Gojković S, and sur.. In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International [Internet]. 2020 May 27 [cited 2024 October 08];2020. doi: 10.1155/2020/6805354

M. Ložić, et al., "In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro", Emergency Medicine International, vol. 2020, May 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:489575. [Accessed: 08 October 2024]

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Metadata
Title (english)In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro
AuthorMarin Ložić
AuthorVasilije Stambolija
AuthorIvan Krezić
AuthorAleksandra Dugandžić
AuthorGordana Živanović-Posilović
AuthorSlaven Gojković
AuthorJosip Kovačević
AuthorLuka Vrdoljak
AuthorIvan Mirković
AuthorAntonio Kokot
AuthorAndreja Petrović
AuthorKatarina Horvat Pavlov
AuthorDomagoj Drmić
AuthorJelena Šuran
AuthorAlenka Boban Blagaić
AuthorSven Seiwerth
AuthorPredrag Sikirić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Recently, the pentadecapeptide BPC 157-induced counteraction of bupivacaine cardiotoxicity has been reported. Medication includes (i) lidocaine-induced local anesthesia via intraplantar application and axillary and spinal (L4-L5) intrathecal block, (ii) lidocaine-induced arrhythmias, (iii) convulsions, and (iv) lidocaine-induced HEK293 cell depolarisation. BPC 157 applications (intraplantar, intraperitoneal, and intragastric) were given (i) immediately after lidocaine, (ii) 10 min after, or (iii) 5 min before. The BPC 157/NO-system relationship was verified with NO-agents, the NOS-blocker L-NAME and the NOS-substrate L-arginine, given alone and/or together, in axillary and spinal intrathecal blocks. BPC 157 applied immediately after lidocaine or 5 min before the application of lidocaine considerably ameliorated plantar presentation. BPC 157 medication considerably counteracted lidocaine-induced limb function failure; L-NAME was counteracted; L-arginine exhibited counteraction when given immediately after lidocaine, but prolongation was seen when given later. Given together, prophylactically or therapeutically, L-NAME and L-arginine (L-NAME + L-arginine) counteracted the other’s response. BPC 157 maintained its original response when given together with L-NAME or L-arginine. When BPC 157 was given together with L-NAME and L-arginine, its original response reappeared. BPC 157 antagonised the lidocaine-induced bradycardia and eliminated tonic-clonic convulsions. Also, BPC 157 counteracted the lidocaine-induced depolarisation of HEK293 cells. Thus, BPC 157 has antidote activity in its own right against lidocaine and local anesthetics.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEmergency Medicine International
Numberingvol. 2020, 6805354
p-ISSN2090-2840
e-ISSN2090-2859
DOIhttps://doi.org/10.1155/2020/6805354
URN:NBNurn:nbn:hr:105:489575
Publication2020-05-27
Document URLhttps://www.hindawi.com/journals/emi/2020/6805354/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-03-24 12:10:52