Kirurško liječenje tumora karotidnog tjelešca

master's thesis

• Title (english): Surgical treatment of carotid body tumors
• Author: Klaudija Hriberski
• Mentor: Predrag Pavić (mentor)
• Committee member: Tomislav Luetić (predsjednik povjerenstva)
• Committee member: Tomislav Meštrović (član povjerenstva)
• Committee member: Predrag Pavić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Surgery); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery

Abstract

Karotidno tjelešce kemoreceptorski je organ smješten u adventiciji karotidne bifurkacije, odgovoran za održavanje homeostaze pO2, pCO2 i pH. Tumori karotidnog tjelešca pripadaju skupini rijetkih tumora i mogu se podijeliti na tri tipa; sporadični, obiteljski i hiperplastični. Najčešće se očituju kao bezbolne tvorbe na lateralnoj strani vrata, koje u uznapredovaloj fazi mogu uzrokovati neurološke simptome i simptome lokalne kompresije. Temelj dijagnostike je ultrazvuk, a CTA, MRA i DSA koriste se u prijeoperacijskoj obradi. Shamblinova klasifikacije dijeli tumore u tri skupine na temelju odnosa tumora s karotidnim arterijama. Zlatni standard liječenja je subadventicijska resekcija; radioterapija i opservacija alternativne su opcije. Kirurška resekcija danas je praćena niskim mortalitetom, ali još uvijek se veže uz značajan rizik neurovaskularne ozljede. Uspješnost operacije može se potencirati primjenom prijeoperacijske devaskularizacije putem embolizacije, ugradnje stenta ili prijeoperacijske radioterapije.

Abstract (english)

The carotid body is a chemoreceptor organ found in adventitia of carotid bifurcation responsible for maintaining homeostatis of pO2, pCO2 i pH. Carotid body tumors belong to the group of rare tumors and can be divided into three types: sporadic, familial and hyperplastic. They most often present as painless mass on the lateral side of the neck and can, in advanced stages, cause neurological symptoms and symptoms of local compression. The base for diagnosis is ultrasound,while CT, MR and angiography are used in preoperative assesment. Shamblin's classification divides these tumors into three groups based on the relationship of the tumor to the carotid arteries. The gold standard of treatment is subadventricular resection; radiotherapy and observation are alternative options. Surgical resection today is accompanied with low mortality, but is still associated with a significant risk of neurovascular injury. The success of the operation can be enhanced by preoperative devascularization, stent implantation or preoperative radiotherapy.

• Keywords: tumori karotidnog tjelešca; karotidni paragangliomi; kirurška resekcija; prijeoperacijska embolizacija
• Keywords (english): carotid body tumors; carotid paraganglioma; surgical resection; preoperative embolization
• Language: croatian
• URN:NBN: urn:nbn:hr:105:014602
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-03-26 13:09:28