Čimbenici rizika za karcinom endometrija

master's thesis

• Title (english): Risk factors for endometrial carcinoma
• Author: Kristina Tomašić
• Mentor: Joško Lešin (mentor)
• Committee member: Goran Vujić (predsjednik povjerenstva)
• Committee member: Dinka Pavičić Baldani (član povjerenstva)
• Committee member: Joško Lešin (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology

Abstract

Karcinom endometrija je najčešće dijagnosticirana maligna promjena reproduktivnog sustava u žena i bolest visoko razvijenog, bogatog društva, čija incidencija i specifična smrtnost imaju tendenciju stalnog rasta zahvaljujući globalnoj epidemiji pretilosti, tjelesnoj neaktivnosti i starenju populacije. Cilj ovog istraživanja je odrediti rizične čimbenike koji utječu na razvoj karcinoma endometrija kod žena u Republici Hrvatskoj. Iz uzorka veličine sto pacijentica liječenih u Klinici za ženske bolesti i porode KBC-a Zagreb tijekom 2016. godine zbog sumnje na karcinom endometrija na temelju anamnestičkih podataka iz medicinske dokumentacije prikupili smo podatke te ih statistički obradili. Istraživanje je pokazalo da je prosječna dob dijagnosticiranja karcinoma endometrija u dobi poslije menopauze što odgovara podatcima do sada utvrđenim kroz literaturu. Reproduktivni čimbenici poput broja porođaja i dobi zadnje menstruacije nisu pokazali značajan utjecaj na razvoj karcinoma endometrija. Više od polovice ispitanica imalo je pozitivnu obiteljsku anamnezu karcinoma. Stanja povećane izloženosti neoponiranom djelovanju estrogena poput prekomjerne tjelesne mase uz pridružene komorbiditete od kojih su najznačajniji hipertenzija i dijabetes melitus ističu se kao važan rizični čimbenik u etiologiji karcinoma endometrija. Prosječan ITM kod ispitanica iznosi 30,94 kg/m2. Na temelju dobivenih rezultata dolazimo do zaključka da promjenjivi rizični čimbenici koji predstavljaju karakteristike životnog stila, a uključuju tjelesnu masu i uz nju vezne bolesti, te tjelesnu neaktivnost, značajno utječu na nastanak karcinoma endometrija. Intervencije u načinu života doprinijele bi prevenciji, ranijem otkrivanju i uspješnijem liječenju karcinoma endometrija.

Abstract (english)

Endometrial cancer is the most commonly diagnosed malignant disorder of the reproductive system in women and a disease of a highly developed, wealthy society, whose incidence and specific mortality tend to grow rapidly due to the global obesity epidemic, physical inactivity and population aging. The aim of this study was to determine the risk factors that affect the development of endometrial cancer in women in the Republic of Croatia. From a sample of one hundred patients treated at the Clinic for Women's Diseases and Obstetrics of the University Hospital Center Zagreb in 2016 due to suspected endometrial cancer, based on anamnestic data from medical records, we collected data and statistically processed them. Results showed that the average age of diagnosis of endometrial cancer is in the postmenopausal age, which corresponds to the data established so far throughout the literature. Reproductive factors such as the number of partity and the age of the last menstruation did not show a significant influence on the development of endometrial cancer. More than half of the respondents had a positive family history of cancer. Conditions of increased exposure to unopposed estrogen for instance overweight with associated comorbidities of which the most significant are hypertension and diabetes
mellitus stand out as an important risk factor in the etiology of endometrial cancer. The average BMI of the respondents is 30.94 kg/m2. In conclusion, variable risk factors, which are characteristics of lifestyle, and include body weight and related diseases as well as physical inactivity, significantly affect the development of endometrial cancer. Lifestyle interventions would contribute to the prevention, earlier detection and more successful treatment of endometrial cancer.

• Keywords: karcinom endometrija; rizični čimbenici; prevencija
• Keywords (english): endometrial cancer; risk factors; prevention
• Language: croatian
• URN:NBN: urn:nbn:hr:105:526466
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-03-26 13:44:42