Volumetrijska analiza razvoja kortikalne i subkortikalne sive tvari kod čovjeka

master's thesis

• Title (english): Volumetric analysis of cortical and subcortical gray matter development in humans
• Author: Dora Mandić
• Mentor: Milan Radoš (mentor)
• Committee member: Goran Šimić (predsjednik povjerenstva)
• Committee member: Mario Vukšić (član povjerenstva)
• Committee member: Milan Radoš (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Radiology); Zagreb
• Defense date and country: 2014-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiology

Abstract

Tijekom razvoja mozga događaju se značajne promjene volumena različitih dijelova mozga i njihovih
omjera. Najveće promjene događaju se u prvim godinama života. Poznavanje normalne dinamike
razvoja kortikalne i subkortikalne sive tvari iznimno je bitno jer omogućuje rano prepoznavanje
poremećenog razvoja mozga te time pruža priliku za raniju primjenu terapijskih procedura. U ovoj
studiji analizirali smo promjene volumena moždanog tkiva na MR snimkama dobivenim snimanjem
sedmero zdrave djece u dvama vremenskim razdobljima. Ispitanici su podijeljeni u dvije dobne
skupine dojenčad i djeca u dobi od dvije godine. Rezultati ove studije pokazali su da u prvim dvjema
godinama života postoji značajan rast volumena kortikalne sive tvari i talamusa. Za razliku od toga,
ukupni volumen bazalnih ganglija ne pokazuje statistički značajnu razliku volumena u ovom
razdoblju. Zaključak ove studije je da se značajan rast volumena kortikalne sive tvari i talamusa
događa postnatalno u prvim godinama života, dok se povećanje volumena bazalnih ganglija odvija
dominantno u prenatalnom razdoblju.

Abstract (english)

In the course of brain development significant changes can be observed in the volumes of different
brain parts and their ratios. The major changes are observed during the first few years of life. It is
essential to be acquainted with the normal dynamic of cortical and subcortical grey matter
development because it allows early detection of defective brain development thus providing an
opportunity for earlier treatment. Therefore, it is vital to determine the normative values in order to
detect certain impairment in the growth of the brain at an early stage and to provide proper treatment.
In this study, we have analyzed the changes in the brain tissue volume in MR images that were
obtained from 7 normal children in two different age groups: infants and two-year-old children. The
results of this study showed a significant increase in the volume of cortical gray matter and thalamus
in the first two years of life. Contrary to this finding, the basal ganglia did not show a statistically
significant difference in volume in the analyzed age groups. The conclusion of this study is that the
significant changes in the volume growth of cortical gray matter and thalamus occur postnatally,
during the first few years of life, while the major changes in the volume growth of basal ganglia occur
prenatally.

• Keywords: razvoj mozga; MR volumetrija; kortikalna siva tvar; subkortikalna siva tvar; bazalni gangliji
• Keywords (english): brain development; MRI volumetry; cortical gray matter; subcortical gray matter; the basal ganglia
• Language: croatian
• URN:NBN: urn:nbn:hr:105:153322
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2015-09-14 09:55:54