Uloga mioinozitola u prevenciji nastanka gestacijskog dijabetesa

master's thesis

• Title (english): The role of myo-inositol in prevention of gestational diabetes
• Author: Karla Kovačić
• Mentor: Trpimir Goluža (mentor)
• Committee member: Josip Juras (predsjednik povjerenstva)
• Committee member: Željko Duić (član povjerenstva)
• Committee member: Trpimir Goluža (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Gestacijski diabetes mellitus stanje je poremećene tolerancije glukoze koje se prvi put javlja u trudnoći i dovodi do stanja kronične hiperglikemije. Jedan je od najčešćih trudničkih poremećaja i zahvaća oko 15 % trudnica diljem svijeta. Osim što nosi brojne rizike
komplikacija trudnoće, gestacijski dijabetes povezan je i s dugoročnim posljedicama za zdravlje i majke i djeteta, osobito u smislu povećanog rizika za kasniji razvitak diabetesa mellitusa tipa 2 i metaboličkog sindroma. Dijagnoza gestacijskog dijabetesa temelji se na testu oralne tolerancije glukoze (OGTT) dok se liječenje prvenstveno temelji na promjeni životnog stila s naglaskom na smanjeni kalorijski unos te umjerenu tjelovježbu. Ako se nefarmakološkim metodama ne uspije postići željena koncentracija glukoze u krvi, prelazi se na farmakološko liječenje oralnim antidijabeticima ili inzulinom. Obećavajuće rezultate u prevenciji gestacijskog dijabetesa pokazuju različiti dodaci prehrani (probiotici, vitamin D i dr.). Brojne studije pokazale su kako mioinozitol, ciklički ugljikohidrat, dan kao prehrambeni suplement od prvog tromjesječja trudnoće do njena završetka smanjuje pojavnost gestacijskog
dijabetesa u žena s povećanim rizikom za njegov razvitak.

Abstract (english)

Gestational diabetes mellitus is a condition of a glucose intolerance which develops during pregnancy and leads to chronic hyperglycemia. It is one of the most common pregnancy disorders that affects about 15 % of pregnant women worldwide. Apart from many pregnancy complications, there is a lot of long-term consequences for both the mother and the child, especially in the terms of increased risk of developing type 2 diabetes and metabolic syndrome later in life. A diagnosis of gestational diabetes is based on an oral glucose tolerance test (OGTT), while the treatment includes lifestyle changes such as calory intake reduction and mild physical activity. If the non-pharmacological methods are not effective in achieving target blood glucose levels, pharmacological methods are a treatment of choice including oral antidiabetics or insulin. Many food suplemments (probiotics, vitamin D, etc.) showed promising results in the prevention of gestational diabetes. Also, studies have shown that myo-inositol, cyclic carbohydrate, given as a suplement from first trimester until delivery, has beneficial impact on the prevention of gestational diabetes for women at risk.

• Keywords: gestacijski diabetes mellitus; test oralne tolerancije glukoze; mioinozitol
• Keywords (english): gestational diabetes mellitus; oral glucose tolerance test; myo-inositol
• Language: croatian
• URN:NBN: urn:nbn:hr:105:733788
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-05-03 08:37:47