Medikamentozno liječenje endometrioze

master's thesis

• Title (english): Medicamentous treatment of endometriosis
• Author: Jelena Lovrenčić
• Mentor: Vladimir Banović (mentor)
• Committee member: Tomislav Župić (predsjednik povjerenstva)
• Committee member: Dinka Pavičić Baldani (član povjerenstva)
• Committee member: Vladimir Banović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Endometrioza je kronična bolest žena reproduktivne dobi koja se klinički manifestira dismenorejom, dispareunijom i smetnjama plodnosti. Dijagnoza se postavlja nakon kliničkog i ultrazvučnog pregleda, a u nekim slučajevima su potrebne laparoskopska vizualizacija i biopsija lezije. Trenutne mogućnosti liječenja uključuju medikamentozno, kirurško i kombinirano liječenje, dok se neplodnost vezana uz endometriozu liječi metodama potpomognute reprodukcije. Farmakološko liječenje se uglavnom bazira na hormonima koji dovode do stanja hipoestrinizma, kao što su gestageni, oralna hormonska kontracepcija i analozi gonadotropin-otpuštajućeg hormona, koji imaju supresivno, ali ne i kurativno djelovanje. Kirurško liječenje se provodi kod endometrioze refraktorne na lijekove te kod opsežnijih lezija, većinom laparoskopski, kako bi se očuvala reproduktivna sposobnost pacijentica. Postoje podijeljena mišljenja oko pristupa liječenju endometrioze, te davanja prednosti medikamentnim ili kirurškim metodama. Sve se više naglašava važnost očuvanja intaktnosti zdjeličnog peritoneuma te očuvanje ovarijske rezerve.

Abstract (english)

Endometriosis is a chronic disease affecting women of reproductive age that manifests with dysmenorrhea, dyspareunia and fertility disorders. Diagnosis is based on clinical and ultrasound examination, whereas in some of the cases, laparoscopic visualization and biopsy of the lesion are required. Current treatment options include pharmacotherapy, surgery, and combined therapy. Infertility associated with endometriosis is treated with assisted reproduction methods. Pharmacotherapy refers to hormones, such as gestagens, oral hormonal contraception, and gonadotropin-releasing hormone analogs, which have suppressive but not curative effects. Surgical treatment is performed in cases of medication refractory disease and extensive lesions. In order to preserve the patient's reproductive ability, laparoscopic approach is used most often. There are divided opinions about medicamentous or surgical treatment, but an importance of maintaining the integrity of the pelvic peritoneum and preserving ovarian reserves, stays mutual.

• Keywords: endometrioza; liječenje; medikamentozno liječenje
• Keywords (english): endometriosis; treatment; medicamentous treatment
• Language: croatian
• URN:NBN: urn:nbn:hr:105:369746
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-05-10 08:16:00