Imunološki aspekt shizofrenije

master's thesis

• Title (english): Immunological aspect of schizophrenia
• Author: Ida Ivek
• Mentor: Martina Rojnić Kuzman (mentor)
• Committee member: Marina Šagud (predsjednik povjerenstva)
• Committee member: Dražen Begić (član povjerenstva)
• Committee member: Martina Rojnić Kuzman (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Psychiatry and Psychological Medicine); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Clinical Immunology

Abstract

Zadnjih dvadesetak godina u fokusu moderne znanosti ponovo je imunološka hipoteza shizofrenije, teorija stara preko sto godina. Cilj ovog rada je prikaz i sistematizacija aktualnih saznanja o neuroinflamaciji kao etiologiji shizofrenije. U svrhu pronalaska relevatne literature pretraživane su baze podataka PubMed/MEDLINE, Clinical Key i Science Direct korištenjem
predmetnica iz rječnika medicinskog nazivlja Medical Subject Headings (MeSH) i pomoću drugih ključnih riječi („schizophrenia“, „immunology“, „neuroinflammation“, ...). Pozivanjem na recentnu literaturu iz područja psihoneuroimunologije, dan je pregled etiopatogeneze shizofrenije iz imunološkog aspekta, predloženi su upalni dijagnostički biomarkeri te adjuvatna antiupalna terapija. Imunološka hipoteza shizofrenije uklapa se u stres-dijatezu koja predlaže da shizofrenija nastaje u genetski podložnih pojedinaca koji izloženi ponavljanom stresu u vulnerabilnom razdoblju aktiviraju neadekvatan imunološki odgovor posljedice kojeg su morfološke promjene mozga, neurokemijski dizbalans i konačno psihopatologija karakteristična za ovu bolest. Velike nedoumice u istraživanju shizofrenije su izrazito neusuglašeni rezultati studija koji proizlaze iz heterogenosti ove bolesti. Ipak, ako su ove hipoteze o etiologiji shizofrenije točne, upalni biomarkeri mogli bi pridonijeti objektivnosti i poslužiti u procesu dijagnostike, a cijeli niz protuupalnih lijekova već dostupnih na tržištu (npr. NSAR, COX-2 inhibitori, omega-3 masne kiseline, ...) mogao bi se uključiti kao adjuvantna terapija uz antipsihotike. Zaključno, vjerojatno je da je inflamacija pozadinski proces u samo jednom od subtipova shizofrenije.

Abstract (english)

Immunological hypothesis of schizophrenia, more than a hundred-year-old theory, has been in very focus of modern science for the last twenty years. The aim of this paper was to review and systematize current findings on neuroinflammation as schizophrenia etiology. In order to find relevant literature, PubMed/MEDLINE, Clinical Key and Science Direct databases were searched by Medical Subject Headings (MeSH) and other keywords (such as “schizophrenia“, “immunology“, “neuroinflammation“, etc.). Based on recent literature from psychoneuroimmunology field, the review on immunological aspect of schizophrenia etiology was given, and diagnostic inflammation biomarkers, as well as possible antiinflammatory adjuvant therapy, were suggested. Immunological hypothesis of schizophrenia is in line with
the stress-diathesis model – a theory suggesting that schizophrenia originates in genetically suspectible individuals or due to repetead stress during the vulnerable period that results in activation of inadequate immunological response which leads to morphological changes of the brain, neurochemical disbalance, and lastly, specific psychopathology. Perplexity of
schizophrenia research lies in substantial inconsistency of study results owing to the heterogeneity of the disease. Nevertheless, if those schizophrenia etiology hypotheses were true, inflammation biomarkers could contribute to objectivity and be of great use in the diagnostic process. Moreover, a plethora of antiinflammatory drugs already on the market
(NSAIDs, COX-2 inhibitors, omega-3 fatty acids, etc.) could be added to antipsychotics as adjuvant therapy. In conclusion, it's possible that inflammation is a background process is only one of many schizophrenia subtypes.

• Keywords: adjuvantna protuupalna terapija; biomarkeri; psihoneuroimunologija; shizofrenija; upala
• Keywords (english): antiinflammatory adjuvant therapy; biomarkers; inflammation; psychoneuroimmunology; schizophrenia
• Language: croatian
• URN:NBN: urn:nbn:hr:105:594021
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-05-12 10:34:15