Utjecaj zdravstvene skrbi na sastav mikrobioma kod novorođenčadi u jedinicama intenzivnog liječenja

master's thesis

• Title (english): The impact of health care on newborn microbiome composition in the neonatal intensive care unit
• Author: Hana Cindrić
• Mentor: Zrinka Bošnjak (mentor)
• Committee member: Ana Budimir (predsjednik povjerenstva)
• Committee member: Goran Tešović (član povjerenstva)
• Committee member: Zrinka Bošnjak (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Medical Microbiology and Parasitology); Zagreb
• Defense date and country: 2020-09-30, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care

Abstract

Novorođenčad koja zahtijeva intenzivnu medicinsku skrb i poduzimanje
postupaka usmjerenih ka spašavanju njihovih života, spada u životno ugroženu
novorođenčad. Tu se ubraja prijevremeno rođena novorođenčad, novorođenčad
s prirođenim anomalijama organa i organskih sustava s potrebom za kirurškim
liječenjem, novorođenčad sa sepsom, meningitisom, metaboličkim bolestima,
konvulzijama. Zdravstvena skrb za novorođenčad u neonatalnoj jedinici
intenzivne njege (JILN) veoma je kompleksna. Noviji i manje poznati fiziološki
aspekt je neonatalni mikrobiom, skup svih mikroorganizama, korisnih i štetnih,
koji nastanjuju ljudsko tijelo. Na neonatalni mikrobiom utječe majčin mikrobiom,
način poroda novorođenčadi i različiti aspekti skrbi u neonatalnim jedinicama
intenzivne njege , kao što su vrsta prehrane, uporaba antibiotika, kontakt koža
na kožu i mehanička ventilacija. Smatra se da sastav i raznolikost mikrobioma
utječe na ključne zdravstvene ishode, uključujući razvoj nekrotizirajućeg
enterokolitisa, kasne neonatalne sepse i loš neurokognitivni razvoj. Medicinske
sestre u JILN-u imaju bitnu ulogu u zdravstvenoj skrbi novorođenčeta, koja
može pozitivno utjecati na mikrobiom, utječući na promicanje optimalnijih
zdravstvenih ishoda kod ove ranjive populacije, stoga je od trenutka prijema u
JILN potrebno započeti razmatranje čimbenika koji utječu na razvoj mikrobioma.

Abstract (english)

Newborns that require intensive medical care and actions aimed at saving
their lives are among the life-threatening newborns. These include premature
infants, infants with congenital anomalies of organs and organ systems in need
of surgical treatment, infants with sepsis, meningitis, metabolic diseases,
convulsions. Health care for newborns in the neonatal intensive care unit
(NICU) is very complex. A newer and lesser known physiological aspect is the
neonatal microbiome, a set of all microorganisms, beneficial and harmful, that
inhabit the human body. The neonatal microbiome is affected by the maternal
microbiome, the mode of delivery of newborns, and various aspects of care in
neonatal intensive care units, such as type of diet, use of antibiotics, skin-toskin contact, and mechanical ventilation. The composition and diversity of the
microbiome are thought to affect key health outcomes, including the
development of necrotizing enterocolitis, late neonatal sepsis, and poor
neurocognitive development. Nurses at NICU play an important role in neonatal
health care that can positively affect the microbiome, promoting more optimal
health outcomes in this vulnerable population, so from the moment of admission
to NICU it is necessary to begin consideration of factors influencing microbiome
development.

• Keywords: Mikrobiom; novorođenče; JILN
• Keywords (english): Microbiome; Newborn; NICU
• Language: croatian
• URN:NBN: urn:nbn:hr:105:860962
• Study programme: Title: Studies in Nursing; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra sestrinstva (magistar/magistra sestrinstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-05-13 11:47:26