Evolucija žarišnih epileptiformnih izbijanja u elektroencefalogramu nedonoščadi s oštećenjem bijele tvari

doctoral thesis

• Title (english): Evolution of focal epileptiform discharges in the electroencephalography of the premature newborn with white matter lesions
• Author: Branka Bunoza
• Mentor: Nina Barišić (mentor)
• Committee member: Vlasta Đuranović (predsjednik povjerenstva)
• Committee member: Vlatka Mejaški-Bošnjak (član povjerenstva)
• Committee member: Ervina Bilić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2021-06-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Neuroscience
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

CILJ:
Istraživanje m smo imali namjeru utvrditi povezanost lokalizacije i oštećenja
bijele tvari s epileptiformnim izbijanjem u EEG u i s neurorazvojnim ishodom nedonoščadi.
----- ISPITANICI I METODE:
Analizirali smo EEG, MR i UZV mozga u 64 nedonoščadi.
Usporedili smo vidljivost i lokalizaciju hipoksično ishemičnih lezija bijele tvari s nalazom EEG a
i neurorazvojnim ishodom. Posebno smo analizirali stupanj vidljivosti segmenta II (periventrikularnog križanja putova crossroads ) s epileptičkim napadajima i neurološkim
----- REZULTATI:
Broj lezija bijele tvari nedonoščadi bio je u pozitivnoj korelaciji s patološkim nalazom EEG a i epileptičkim napadajima u novorođenačkoj dobi. Nije utvrđena
pozitivna korelacija sa zahvaćenošću pojedinačnih režnjeva, komora, bazalnih ganglija i
malog mozga. Istraživanjem je uočena pozitivna korelacija između slabije vidljivosti segmenta II frontalno i parijetalno u terminu s češćom prisutnošću epileptičkih napadaja u novorođenačkoj dobi i kasnijim lošijim neurološkim ishodom.
----- ZAKLJUČAK:
Rezultati koje smo dobili ukazuju kako brojna oštećenja bijele tvari
nedonoščadi pridonose epileptogenezi. Od pojedinačnih lokalizacija, mogući prognostički
marker neurorazvojnog ishod a je vidljivost segmenta II na MR u mozga u terminu predviđena
poroda kao mjesta važna križanja komisuralnih, projekcijskih i asocijativnih vlakana tijekom
razvoja mozga.

Abstract (english)

AIM: Advances in neonatal medicine has dramatically improved survival rate of pre-
term infants that are frequently born with numerous neurodevelopmental disabilities including
epileptic seizures and epilepsy. In this dissertation the hypothesis was that localisation of white
matter injury is associated with epileptiform EEG changes and neurodevelopmental outcome.
----- MATERIALS AND METHODS:
In 64 preterm infants we analyzed EEG, brain MRI
and ultrasound and motor d evelopment. We evaluated the relationship of brain white matter
lesion with EEG and lesions of certain brain localisation (segment II crossroads, parietal,
temporal, occipital lobe, basal ganglia, cerebellum and ventriculomegaly) with epileptic seizu-
res and neurodevelopmental outcome.
----- RESULTS:
The total number of white matter lesions was in a positive correlation
with the pathological EEG findings and epileptic seizures in infants. Infants who did not have
visible anterior and posterior crossroads frequen tly had epileptic seizures during newborn
period and worse neurodevelopmental outcome.
----- Conclusion:
The obtained results indicate that white matter damage is associated with
epileptogenesis. Among individual localization, the visibility of segment II as the place where
commissural, projection and associative fibers are crossing has a prognostic value for the
future neurodevelopmental outcome. Further studies are needed in order to determine the
pathogenic factors that contribute to epileptogenesis in infants with white matter lesions.

• Keywords: oštećenja bijele tvari; epileptiforno izbijanje; neurorazvoj; nedonoščad; EEG
• Keywords (english): white matter damage; epileptiphoric eruption; neurodevelopment; premature infants; EEG
• Language: croatian
• URN:NBN: urn:nbn:hr:105:071383
• Promotion: 2021
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 99 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-08-04 07:18:29