Rani prijevremeni porod

master's thesis

• Title (english): Very preterm birth
• Author: Ivana Oklopčić
• Mentor: Ivanka Bekavac Vlatković (mentor)
• Committee member: Alan Šerman (predsjednik povjerenstva)
• Committee member: Željko Duić (član povjerenstva)
• Committee member: Ivanka Bekavac Vlatković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Rani prijevremeni porod je porod između 28. i 32. tjedna trudnoće. Prijevremeni porod predstavlja globalni problem i nosi rizike za razvoj niza kratkoročnih i dugoročnih posljedica. Iako se povezuje s raznim rizičnim čimbenicima, etiologija i patogeneza i danas ostaju svojevrsna nepoznanica. Zbog nezrelosti brojnih organa i organskih sustava, nedonošenost je najčešći uzrok novorođenačkih i dojenačkih smrti te je među vodećim uzrocima cerebralne paralize i neurorazvojnih poremećaja. Predstavlja problem i što se tiče dijagnostike, pošto najčešće nema jasnu kliničku sliku i rane simptome, nego se očituje upravo prijevremenim rađanjem, a suvremena se terapija temelji na odgađanju poroda i sprječavanju komplikacija nedonošenosti. S napretkom tehnologije i medicine, odnosno neonatalne intenzivne njege, preko 90% nedonoščadi preživi rani prijevremeni porod. Unatoč tome, šanse za razvoj dugoročnih posljedica i teških tjelesnih i duševnih nedostataka relativno su visoke, što predstavlja financijsko, ali i socijalno i emocionalno opterećenje. Zbog nejasne etiologije i patogeneze, otežane dijagnostike te nemogućnosti liječenja uzroka, prijevremeni porod predstavlja velike izazove u strategijama prevencije i liječenja te je zbog toga materijal vrijedan daljnjeg istraživanja.

Abstract (english)

Very preterm birth occurs between 28th and 32nd week of pregnancy. Preterm birth represents a big global problem and it can cause short-term and long-term consequences. Even though it's connected with lots of risk factors, etiology and pathogenesis remain unknown. Because of immaturity of numerous organs and organ systems, prematurity is the most common cause of neonatal and infant deaths and it's one of the leading causes of cerebral palsy and other neurodevelopmental sequelae. It mostly presents with preterm onset of labor without early symptoms or other specific clinical findings, and that’s why it’s also a diagnostic issue. Once labor begun, contemporary medicine suggests delaying labor and preventing neonatal complications because no causal treatment is available. With technological and medical improvements, especially of neonatal intensive care, more than 90% of premature infants survives very preterm birth. However, there is relatively high risk for development of long-term consequences and severe handicaps that represent financial and socioemotional burden. Its unclear etiology and pathogenesis, diagnostic problems and non-causal treatment represent big challenges in strategies of preventions and treatment and because of that it's a material worth of further research.

• Keywords: rani prijevremeni porod; nedonešenost; komplikacije trudnoće
• Keywords (english): very preterm birth; prematurity; pregnancy complications
• Language: croatian
• URN:NBN: urn:nbn:hr:105:061574
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-08-27 08:56:18