Effects of Environmental Factors on Severity and Mortality of COVID-19

Kifer, Domagoj; Bugada, Dario; Villar-Garcia, Judit; Gudelj, Ivan; Menni, Cristina; Sudre, Carole; Vučković, Frano; Ugrina, Ivo; Lorini, Luca F.; Posso, Margarita; Bettinelli, Silvia; Ughi, Nicola; Maloberti, Alessandro; Epis, Oscar; Giannattasio, Cristina; Rossetti, Claudio; Kalogjera, Livije; Peršec, Jasminka; Ollivere, Luke; Ollivere, Benjamin J.; Yan, Huadong; Cai, Ting; Aithal, Guruprasad P.; Steves, Claire J.; Kantele, Anu; Kajova, Mikael; Vapalahti, Olli; Sajantila, Antti; Wojtowicz, Rafal; Wierzba, Waldemar; Krol, Zbigniew; Zaczynski, Artur; Zycinska, Katarina; Postula, Marek; Lukšić, Ivica; Čivljak, Rok; Markotić, Alemka; Brachmann, Johannes; Markl, Andreas; Mahnkopf, Christian; Murray, Benjamin; Ourselin, Sebastien; Valdes, Ana M.; Horcajada, Juan P.; Castells, Xavier; Pascual, Julio; Allegri, Massimo; Primorac, Dragan; Spector, Tim D.; Barrios, Clara; Lauc, Gordan

doi:10.3389/fmed.2020.607786

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Scientific paper - Original scientific paper

Effects of Environmental Factors on Severity and Mortality of COVID-19

Frontiers in Medicine, 7 (2021); 607786. https://doi.org/10.3389/fmed.2020.607786

Kifer, Domagoj; Bugada, Dario; Villar-Garcia, Judit; Gudelj, Ivan; Menni, Cristina; Sudre, Carole; Vučković, Frano; Ugrina, Ivo; Lorini, Luca F.; Posso, Margarita; Bettinelli, Silvia; Ughi, Nicola; Maloberti, Alessandro; Epis, Oscar; Giannattasio, Cristina; Rossetti, Claudio; Kalogjera, Livije; Peršec, Jasminka; Ollivere, Luke; Ollivere, Benjamin J.; Yan, Huadong; Cai, Ting; Aithal, Guruprasad P.; Steves, Claire J.; Kantele, Anu; Kajova, Mikael; Vapalahti, Olli; Sajantila, Antti; Wojtowicz, Rafal; Wierzba, Waldemar; Krol, Zbigniew; Zaczynski, Artur; Zycinska, Katarina; Postula, Marek; Lukšić, Ivica; Čivljak, Rok; Markotić, Alemka; Brachmann, Johannes; Markl, Andreas; Mahnkopf, Christian; Murray, Benjamin; Ourselin, Sebastien; Valdes, Ana M.; Horcajada, Juan P.; Castells, Xavier; Pascual, Julio; Allegri, Massimo; Primorac, Dragan; Spector, Tim D.; Barrios, Clara; Lauc, Gordan More authors...

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APA 6th Edition

Kifer, D., Bugada, D., Villar Garcia, J., Gudelj, I., Menni, C., Sudre, C. ... Lauc, G. (2021). Effects of Environmental Factors on Severity and Mortality of COVID-19. Frontiers in Medicine, 7.. doi: 10.3389/fmed.2020.607786

MLA 8th Edition

Kifer, Domagoj, et al. "Effects of Environmental Factors on Severity and Mortality of COVID-19." Frontiers in Medicine, vol. 7, 2021. https://doi.org/10.3389/fmed.2020.607786

Chicago 17th Edition

Kifer, Domagoj, Dario Bugada, Judit Villar Garcia, Ivan Gudelj, Cristina Menni, Carole Sudre, Frano Vučković, et al. "Effects of Environmental Factors on Severity and Mortality of COVID-19." Frontiers in Medicine 7 (2021). https://doi.org/10.3389/fmed.2020.607786

Harvard

Kifer, D., et al. (2021) 'Effects of Environmental Factors on Severity and Mortality of COVID-19', Frontiers in Medicine, 7. doi: 10.3389/fmed.2020.607786

Vancouver

Kifer D, Bugada D, Villar Garcia J, Gudelj I, Menni C, Sudre C, and sur.. Effects of Environmental Factors on Severity and Mortality of COVID-19. Frontiers in Medicine [Internet]. 2021 January 20 [cited 2024 October 13];7. doi: 10.3389/fmed.2020.607786

IEEE

D. Kifer, et al., "Effects of Environmental Factors on Severity and Mortality of COVID-19", Frontiers in Medicine, vol. 7, January 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:593227. [Accessed: 13 October 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:593227

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Title (english)	Effects of Environmental Factors on Severity and Mortality of COVID-19
Author	Domagoj Kifer
Author	Dario Bugada
Author	Judit Villar-Garcia
Author	Ivan Gudelj
Author	Cristina Menni
Author	Carole Sudre
Author	Frano Vučković
Author	Ivo Ugrina
Author	Luca F. Lorini
Author	Margarita Posso
Author	Silvia Bettinelli
Author	Nicola Ughi
Author	Alessandro Maloberti
Author	Oscar Epis
Author	Cristina Giannattasio
Author	Claudio Rossetti
Author	Livije Kalogjera
Author	Jasminka Peršec
Author	Luke Ollivere
Author	Benjamin J. Ollivere
Author	Huadong Yan
Author	Ting Cai
Author	Guruprasad P. Aithal
Author	Claire J. Steves
Author	Anu Kantele
Author	Mikael Kajova
Author	Olli Vapalahti
Author	Antti Sajantila
Author	Rafal Wojtowicz
Author	Waldemar Wierzba
Author	Zbigniew Krol
Author	Artur Zaczynski
Author	Katarina Zycinska
Author	Marek Postula
Author	Ivica Lukšić
Author	Rok Čivljak
Author	Alemka Markotić
Author	Johannes Brachmann
Author	Andreas Markl
Author	Christian Mahnkopf
Author	Benjamin Murray
Author	Sebastien Ourselin
Author	Ana M. Valdes
Author	Juan P. Horcajada
Author	Xavier Castells
Author	Julio Pascual
Author	Massimo Allegri
Author	Dragan Primorac
Author	Tim D. Spector
Author	Clara Barrios
Author	Gordan Lauc
Author's institution	University of Zagreb School of Medicine (Department of Infectious Diseases)
Author's institution	University of Zagreb School of Medicine (Department of Maxillofacial Surgery and Dentistry)
Author's institution	University of Zagreb School of Medicine (Department of Othorhinolaryngology and Head and Neck Surgery)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Otorhinolaryngology
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Infectology
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Surgery
Abstract (english)	Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. ----- Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application. ----- Findings: Meta-analysis of the mortality risk in seven European hospitals estimated odds ratios per 1-day increase in the admission date to be 0.981 (0.973-0.988, p < 0.001) and per increase in ambient temperature of 1°C to be 0.854 (0.773-0.944, p = 0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to the intensive care unit, and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time. ----- Interpretation: Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Frontiers in Medicine
Numbering	vol. 7, 607786
e-ISSN	2296-858X
DOI	https://doi.org/10.3389/fmed.2020.607786
URN:NBN	urn:nbn:hr:105:593227
Publication	2021-01-20
Document URL	https://www.frontiersin.org/articles/10.3389/fmed.2020.607786/full
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2021-09-24 09:02:14