Title Day-2 serum progesterone level and IVF/ICSI outcome Title (croatian) Povezanost serumskih vrijednosti progesterona drugog dana menstruacijskog ciklusa sa ishodima IVF/ICSI Author Ana Mičić Mentor Lana Škrgatić (mentor)Committee member Lana Škrgatić (predsjednik povjerenstva)Committee member Marina Šprem Goldštajn (član povjerenstva)Committee member Dinka Pavičić Baldani (član povjerenstva)Granter University of Zagreb Defense date and country 2020-07-17, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Infertility in couples is common and has become a global burden, remaining high over the years. The National Institute for Health and Care Excellence (NICE) recommends that prolonged or unresolved infertility should be treated using assisted reproduction technology. The purpose of this study was to evaluate the impact of elevated day-2 serum progesterone levels on IVF and ICSI
outcome regarding pregnancy. A one-center cohort retrospective study was conducted during the period of February 2020 to May 2020. The study includes data from 136 patients who underwent a total of 189 fresh embryo transfers in IVF/ICSI antagonist cycles from January 2014 to January 2020. Based on the levels of day-2 serum progesterone the total number of cases (n=189) were divided into two groups; group 1 (n=134) with serum progesterone level of ≤1.5 ng/mL (normal) and group 2 (n=55) with serum progesterone level of >1.5 ng/mL (high). The total dose of gonadotropins, age, BMI, AMH, FSH, LH, PRL, the number of oocytes retrieved, the number of embryos transferred and frozen, and positive pregnancy tests were compared between the two groups. The results showed that there was no statistically significant difference between age, BMI, AMH, FSH, LH, PRL, total dose of gonadotropins, the number of oocytes retrieved, and the technique used (IVF or ICSI) between the two groups. As well there was no statistically significant difference between the two groups in regards to the number of embryos transferred and the number of frozen embryos. Although a higher percentage of pregnancies based on positive hCG was found in the normal progesterone level group (33.6%) than in the high progesterone group (23.8%), there was no statistically significant difference
between the two groups (p-value 0.178). In conclusion, this study found that an elevated day-2 serum progesterone level does not have a significant impact on the clinical outcome of IVF/ICSI antagonist cycles with fresh embryo transfers.
Abstract (croatian) Neplodnost predstavlja globalni problemi uz visoku pojavnost tijekom godina. Nacionalni institut za izvrsnost u području zdravstva i skrbi (NICE) preporuča liječenje dugogodišnje ili idiopatske neplodnosti medicinski pomognutom oplodnjom. Cilj ove studije bio je istražiti utjecaj povišenih vrijednost serumskog progesterona drugog dana menstruacijskog ciklusa sa ishodima IVF/ICSI vezanim uz trudnoću. Provedena je kohortna retrospektivna studija u razdoblju od veljače 2020. do svibnja 2020. Istraživanje je uključilo podatke od 136 pacijentica koje su od siječnja 2014. do siječnja 2020. prošle ukupno 189 antagonistički ciklusa IVF/ICSI koje su uključivale svježi embriotransfer. Ovisno o serumskoj razini progesterona 2. dana ciklusa, ukupni broj slučajeva (n=188) podijeljen je u dvije skupine; skupina 1 (n=134) s razinom progesterona u serumu od ≤1,5 ng/mL (normalna razina progesterona) i skupina 2 (n=55) s razinom progesterona u serumu >1,5 ng/mL (visoki progesteron). Uspoređivana je ukupna doza gonadotropina, dob, ITM, AMH, FSH, LH, PRL, broj aspiriranih oocita i broj transferiranih i zamrznutih embrija između obje skupine. Nisu nađene statistički značajne razlike između dobi, ITM, AMH, FSH, LH, PRL kao niti ukupne doze korištenih gonadotropina, broja aspiriranih oocita između dviju skupina. Nije nađena niti značajna razlika između broja transferiranih embrija i broja zamrznutih embrija između istraživanih skupina. Utvrđen je veći postotak trudnoća s pozitivnim hCG-om u skupini sa normalnom razinom progesterona (33.6%) u odnosu na skupinu s visokim progesteronom (23.8%), ali ova razlika nije statistički značajna (p vrijednost 0.178). Zaključno, rezultati ove studije pokazuju da povišena razina serumskog progesterona drugog dana ciklusa nema značajan utjecaj na ishode IVF/ICSI.
Keywords
in vitro fertilization
intracytoplasmic sperm injection
progesterone
pregnancy
Keywords (croatian)
in vitro oplodnja (IVF)
intracitoplazmatska injekcija spermija (ICSI)
progesteron
trudnoća
Language english URN:NBN urn:nbn:hr:105:406211 Study programme Title: Medicine (in English language) Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2021-10-07 11:41:51
