The benzodiazepine nation of Croatia: a retrospective, observational, comparative study of psychotropic drug utilization between Croatia and Sweden 2014-2015

master's thesis

• Title (croatian): Benzodijazepinska nacija Hrvatske: opservacijsko, komparativno istraživanje utilizacije psihotropnih lijekova između Hrvatske i Švedske u 2014. i 2015. godini
• Author: Eric Guhyun Nham
• Mentor: Robert Likić (mentor)
• Committee member: Robert Likić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Milan Milošević (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Pharmacology

Abstract

BACKGROUND: The consumption of psychotropic drugs (PD) is increasing worldwide with a significant variation between countries. Croatia and Sweden have similar health and pharmaceutical systems; however, Sweden is a high-income country with developed medical care, registries, and prescribing guidelines. We sought to compare the utilization of PD between Croatia and Sweden to identify areas for improvement in rational use of drugs. ----- METHODS: This was a cross-sectional study using national databases to assess utilization of PD (ATC N05, N06) in Croatia and Sweden in 2014 and 2015. ----- RESULTS: Prescribing of PD in Croatia increased from 127 DDD/TID (defined daily dose/1000 inhabitants) in 2014 to 131 DDD/TID in 2015. In Sweden, the total utilization was higher with an increase from 183 DDD/TID in 2014 to 188 DDD/TID in 2015. There were substantial differences. In Croatia, the utilization of benzodiazepine derivatives (N05BA) was 72.5 DDD/TID in 2014 and increased to 74.4 DDD/TID, in 2015. In Sweden, the utilization was only 11.2 DDD/TID for benzodiazepine derivatives in both years. ----- CONCLUSIONS: There were substantial differences in utilization of PD between Croatia and Sweden. Highlighting the problem of inappropriate benzodiazepine utilization in Croatia can help to introduce measures to change prescribing habits and improve prescribing quality.

Abstract (croatian)

POZADINA: Potrošnja psihotropnih lijekova (PD) povećava se širom svijeta sa znatnim odstupanjima između zemalja. Hrvatska i Švedska imaju slične zdravstvene i farmaceutske sustave; međutim, Švedska je zemlja s visokim dohotkom s razvijenom medicinskom skrbi, registrima i propisivanjem smjernica. Pokušali smo usporediti uporabu PD-a između Hrvatske i Švedske kako bi se identificirala područja za poboljšanje racionalne uporabe droga. ----- METODE: Ovo je bila presječna studija koja je koristila nacionalne baze podataka za procjenu korištenja PD-a (ATC N05, N06) u Hrvatskoj i Švedskoj u 2014. i 2015. godini. ----- REZULTATI: Propisivanje PD u Hrvatskoj povećalo se sa 127 DDD / TID (definirana dnevna doza / 1000 stanovnika) u 2014. na 131 DDD / TID u 2015. U Švedskoj je ukupna iskorištenost bila veća s porastom od 183 DDD / TID u 2014. na 188 DDD / TID u 2015. Bilo je značajnih razlika. U Hrvatskoj je upotreba derivata benzodiazepina (N05BA) u 2014. iznosila 72,5 DDD / TID i povećala se na 74,4 DDD / TID u 2015. U Švedskoj je upotreba bila samo 11,2 DDD / TID za benzodiazepinske derivate u obje godine. ----- ZAKLJUČCI: Postoje značajne razlike u korištenju PD-a između Hrvatske i Švedske. Isticanje problema neprimjerene upotrebe benzodiazepina u Hrvatskoj može pomoći uvođenju mjera za promjenu navika propisivanja i poboljšanje kvalitete propisivanja.

• Keywords: benzodiazepines; drug safety; drug utilization; prescribing; psychotropic drugs
• Keywords (croatian): benzodiazepini; sigurnost lijekova; korištenje droga; propisivanje; psihotropni lijekovi
• Language: english
• URN:NBN: urn:nbn:hr:105:016061
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-10-07 12:21:07