Meibomian gland dysfunction

master's thesis

• Title (croatian): Disfunkcija meibomovih žlijezda
• Author: Ivan Štimac Rojtinić
• Mentor: Igor Petriček (mentor)
• Committee member: Igor Petriček (predsjednik povjerenstva)
• Committee member: Miro Kalauz (član povjerenstva)
• Committee member: Nenad Vukojević (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Ophthalmology and Optometry); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Ophthalmology

Abstract

Meibomian gland disease (MGD) is defined as chronic and disperse dysfunction of Meibomian glands. MGD is a disease that can be acquired or congenital. This disease is recognized as an obstruction of the terminal duct of the gland and changes in the composition of the tear film. MGD covers the part of Dry eye disease (DED) that is known as evaporative dry eye (EDE). EDE is connected to the lipid part of the tear film. The lipid part of the tear film plays an important role in stabilizing the tear film, without the lipid component the tear film evaporation time dramatically decreases. With the decrease of tear film stability some of the symptoms can start showing. The most common type of MGD is obstructive MGD. Obstructive MGD encompases a lot of subtypes but the most important one would have to be hyperkeratinization. Hyperkeratinization is important because the process of obstruction is directly connected to the histology and embryology of the glands. MDG has a specific parent of presentation, because of that there are a lot of methods that can be used to diagnose the disease. Although the methods used for diagnosis are precise and up to date there is a need to combine the different test to get the most accurate result. Finally the treatment for MDG is not complicated but some aspects of it can prove to be challenging for the patient whilst others may be painfull.

Abstract (croatian)

Bolest meibomanske žlijezde (MGD) definirana je kao kronična i disperzna disfunkcija meibomanskih žlijezda. MGD je bolest koja može biti stečena ili urođena. Ova je bolest prepoznata kao začepljenje terminalnog kanala žlijezde i promjena u sastavu suznog filma. MGD pokriva dio bolesti suhog oka (DED) koji je poznat pod nazivom evaporativno suho oko (EDE). EDE je povezan s lipidnim dijelom suznog filma. Lipidni dio suznog filma igra važnu ulogu u stabilizaciji suznog filma, bez lipidne komponente vrijeme isparavanja suza filma dramatično se smanjuje. S padom stabilnosti suznog filma neki od simptoma mogu se početi prikazivati. Najčešća vrsta MGD je opstruktivni MGD. Opstruktivni MGD obuhvaća puno podvrsta, ali najvažnija od njih bi trebala biti hiperkeratinizacija. Hiperkeratinizacija je važna jer je proces opstrukcije izravno povezan s histologijom i embriologijom žlijezda. MDG ima specifičnu strukturu prezentacije, zbog čega postoji puno metoda pomoću kojih se može dijagnosticirati bolest. Iako su metode koje se koriste za dijagnozu precizne i suvremene, postoji potreba da se kombiniraju različiti testovi kako bi se dobio najprecizniji rezultat. Konačno, liječenje MDG-a nije komplicirano, ali neki njegovi aspekti mogu se pokazati izazovnim za pacijenta, dok drugi mogu biti bolni.

• Keywords: hyperkeratinization; evaporative dry eye; evaporation
• Keywords (croatian): hiperkeratinizacija; evaporativno suho oko; evaporacija
• Language: english
• URN:NBN: urn:nbn:hr:105:138093
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-10-08 11:24:52