Raynaud's phenomenon in children and adolescents

master's thesis

• Title (croatian): Raynaudov fenomen kod djece i adolescenata
• Author: Nikola Škreb
• Mentor: Marija Jelušić (mentor)
• Committee member: Marija Jelušić (predsjednik povjerenstva)
• Committee member: Irena Senečić-Čala (član povjerenstva)
• Committee member: Jurica Vuković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pediatrics); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract

Raynaud's phenomenon (RP) is a condition characterized by increased and exaggerated vasoreactivity to cold temperatures and mental stress. Computerized colour telethermography (CCTT) is an established diagnostic procedure in clinical practice that is used for assessment and follow-up of patients with microcirculatory disorders. Objective of this study was to analyze the diagnostic value of CCTT and its use in the diagnosis of RP. CCTT results were interpreted to determine occurrence and prevalence of both primary Raynaud's phenomenon (PRP) and secondary Raynaud's phenomenon (SRP) according to sex and age. We conducted a retrospective investigation and analysis of medical records and CCTT results from 464 pediatric patients under the clinical and anamnestic suspicion of RP in a 14-year period. Prevalence of PRP and SRP was calculated in the total targeted pediatric sample as well as separately female and male prevalence of both disease variants. Patients were categorized into three different age groups to determine differences in age distribution. Pearson's chi-squared test was used to assess the correlation between sex and case distribution, and correlation between age and case distribution. Results showed prevalence of 12.93% of PRP and prevalence of 25.43% of SRP in the targeted sample. There was a clear difference in sex distribution, with males showing higher prevalence of SRP and negative cases, and females showing higher prevalence of PRP. Correlation between sex and case distribution did not prove to be statistically significant (p=0.26). Late adolescence has been demonstrated as the most affected group, showing significantly higher prevalence of both PRP and SRP and significantly lower prevalence of negative cases. This age group has also been proven as statistically significant factor (p=0.0024) for the occurrence of RP when compared to early adolescence. Based on these results, there is increased risk of RP occurrence in the female population and in late adolescence.

Abstract (croatian)

Raynaudov fenomen (RP) je poremećaj karakteriziran povećanom i pretjeranom vazoreaktivnošću na hladne temperature i mentalni stres. Kompjuterizirana kolor teletermografija (CCTT) je utemeljeni dijagnostički postupak u kliničkoj praksi koji se koristi za procjenu i praćenje bolesnika s poremećajima mikrocirkulacije. Cilj ovog istraživanja je analizirati dijagnostičku vrijednost CCTT-a i uporabu u dijagnostici RP. Rezultati CCTT-a interpretirani su kako bi se odredila pojava i prevalencija primarnog Raynaudovog fenomena (PRP) i sekundarnog Raynaudovog fenomena (SRP) prema spolu i dobi. Provedeno je retrospektivno istraživanje i analiza medicinskih nalaza i CCTT rezultata kod 464 pedijatrijskih pacijenata pod kliničkom i anamnestičkom sumnjom na RP u 14-godišnjem razdoblju. Prevalencija PRP-a i SRP-a izračunata je u ukupnom ciljanom pedijatrijskom uzorku, kao i posebno ženska i muška prevalencija obje varijante bolesti. Pacijenti su razvrstani u tri različite dobne skupine kako bi se utvrdile razlike u distribuciji po dobi. Pearsonov hi-kvadrat test je korišten za procjenu povezanosti spola i raspodjele slučajeva, te povezanosti između dobi i raspodjele slučajeva. Rezultati rada su pokazali prevalenciju PRP-a od 12,93% i prevalenciju SRP-a od 25,43% u ciljanom uzorku. Dokazana je jasna razlika u spolnoj distribuciji, pri čemu su muškarci pokazali veću prevalenciju SRP-a i negativnih slučajeva, a žene veću prevalenciju PRP-a. Povezanost između spola i raspodjele slučajeva nije se pokazala statistički značajnom (p = 0,26). Kasna adolescencija pokazala se kao najvulnerabilnija grupa, uz značajno veću prevalenciju i PRP-a i SRP-a i značajno nižu prevalenciju negativnih slučajeva. Ova dobna skupina se dokazala i kao statistički značajan faktor (p = 0,0024) za pojavu RP-a u usporedbi s ranom adolescencijom. Temeljem ovih rezultata određen je povećan rizik od pojave RP-a u ženskoj populaciji i u kasnoj adolescenciji.

• Keywords: Raynaud's phenomenon; CCTT; children; adolescence
• Keywords (croatian): Raynaudov fenomen; CCTT; djeca; adolescencija
• Language: english
• URN:NBN: urn:nbn:hr:105:364977
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-10-08 11:44:20