Učinkovitost grupne suportivne psihoterapije u liječenju shizofrenije

doctoral thesis

• Title (english): Group suportive psychotherapy efficacy in treatment of schizophrenia
• Author: Nataša Đuran
• Mentor: Neven Henigsberg (mentor)
• Committee member: Slađana Štrkalj-Ivezić (predsjednik povjerenstva)
• Committee member: Rudolf Gregurek (član povjerenstva)
• Committee member: Darko Marčinko (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2021, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Raspoložive farmakološke i psihosocijalne metode još uvijek kod velikog broja pacijenata
ne dovode do zadovoljavajućih rezultata za oboljele od shizofrenije. Brojna istraživanja i
kliničko iskustvo upućuju da bi grupna psihoterapija mogla pomoći u poboljšanju ishoda
liječenja, stoga je važno istražiti ovo područje kako bi se mogli definirati standardi za
psihijatrijsku praksu. Hipoteza našeg istraživanja bila je da su bolesnici oboljeli od
shizofrenije liječeni GSP i farmakoterapijom rjeđe su rehospitalizirani tijekom prvih 12
mjeseci nakon otpusta, nego bolesnici oboljeli od shizofrenije liječeni samo
farmakoterapijom. Za potrebu provjere te hipoteze proveli smo unicentičnu, randomiziranu
kontroliranu, nezaslijepljenu studiju u Zavodu za integralnu psihijatriju I Klinike za
psihijatriju Vrapče tijekom 2015. i 2016. godine. Protokol istraživanja odobrila su Etička
povjerenstva Klinike za psihijatriju Vrapče i Medicinskog fakulteta Sveučilišta u Zagrebu. U
istraživanje smo uključili 121 bolesnika pa ih 60 nasumično podijelili u skupinu liječenu GSP
i standardnom farmakoterapijom, a 60 u skupinu liječenu samo standardnom
farmakoterapijom. Nismo potvrdili učinak GSP na rjeđe rehospitalizacije tijekom prvih 12
mjeseci niti na kvalitetu života tri mjeseca nakon završetka intervencije. Potvrdili smo učinke
GSP na smanjivanje težine pozitivnih simptoma shizofrenije, ali moguće čak i nepovoljne
učinke na negativne psihotične simptome, na autistične simptome te na simptome uzbuđenja.
Rezultati upućuju na potrebu uvođenja protokola za provođenje kratke bolničke
psihoterapije koji bi uključio ciljeve i postupke koji će potaknuti procese ego osnaženja.

Abstract (english)

Therapies for schizophrenia available today are unsatisfactory in a relatively large
number of patients. Group supportive, psychodynamically oriented psychotherapy is a
relatively affordable intervention of lower cost and duration and could be used as adjunctive
therapy to standard psychopharmaceutical therapy and other psychotherapeutic methods. The
hypothesis of our study was that patients with schizophrenia treated with GSP and
pharmacotherapy were less likely to be rehospitalized during the first 12 months after
discharge than patients with schizophrenia treated with pharmacotherapy alone. To test this
hypothesis, we conducted a unicentric, randomized controlled, non-blinded study at the
Department of Integral Psychiatry and the Clinic for Psychiatry Vrapče during 2015 and
2016. The study protocol was approved by the Ethics Committees of the Clinic for
Psychiatry Vrapče and the Faculty of Medicine, University of Zagreb. We included 121
patients in the study, and randomly allocated 60 of them into the group treated with GSP and
standard pharmacotherapy, and 60 into the group treated with standard pharmacotherapy
only. We did not confirm the effect of GSP on less frequent rehospitalizations during the first
12 months, nor on quality of life three months after the end of the intervention. We
confirmed the effects of GSP on reducing the severity of positive symptoms of
schizophrenia, but possibly even adverse effects on negative psychotic symptoms, on autistic
symptoms, and on arousal symptoms.

• Keywords: Kvaliteta života; Shizofrenija; Otpust bolesnika; Psihoterapija; Psihotični poremećaji; Terapija kombiniranog modaliteta; Psihijatrija; Psihotropni lijekovi
• Keywords (english): Quality of Life; Schizophrenia; Patient Discharge; Psychotherapy; Psychotic Disorders; Combined Modality Therapy; Psychiatry; Psychotropic Drugs
• Language: croatian
• URN:NBN: urn:nbn:hr:105:351468
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 116 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-10-25 09:50:25