Ultrazvučna analiza mezencefaličkih jezgara u bolesnika s Parkinsonovom bolesti s depresivnim simptomima i bez depresivnih simptoma

doctoral thesis

• Title (english): Ultrasonographyc analysis of mesencephalic nuclei in patients with Parkinson's disease with and without depressive symptoms
• Author: Katarina Blažina
• Mentor: Maja Relja (mentor)
• Committee member: Fran Borovečki (predsjednik povjerenstva)
• Committee member: Alma Mihaljević-Peleš (član povjerenstva)
• Committee member: Zlatko Trkanjec (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2021, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Neurology
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Parkinsonova bolest druga je neurodegenerativna bolest iza Alzheimerove demencije te je rana dijagnostika važan faktor koji doprinosi pravovremenom liječenju a time i poboljšanju kvalitete života bolesnika.
Ovim istraživanjem analizirano je značenje nalaza TCD-a u PB-i kao i premotoričkim simptomima, prvenstveno depresiji.
Osnovna hipoteza istraživanja bila je da ultrazvučna analiza mezencefaličkih jezgara može dati različiti rezultat u bolesnika s depresijom u sklopu PB-i u odnosu na bolesnike bez depresije, što može doprinijeti u prepoznavanju ranog nemotoričkog znaka PB-i.
Istraživanje je provedeno na 150 bolesnika s PB-i, 52 bolesnika s depresijom te 100 kontrola ( ispitanici bez simptoma PB-i ili depresije). Kod svih ispitanika izvršena je analiza bazalnih ganglija TCD-om ( Aloka prosound α-10) u jednom navratu.
Stupanj bolesti u PD-a određen je UPDRS i H&Y skalom dok je stupanj depresije u svim ispitanim skupinama određen BECK-ovom skalom.
Rezultati su pokazali značajnu razliku nalaza TCD-a prvenstveno na nivou bazalnih ganglija između bolesnika s PB-i s i bez depresije kao i između oboljelih od PB-i i velikog depresivnog poremećaja. Utvrdili smo da površina SN korelira s rezultatom BDI, što je rezultat viši veća je površina SN koja se do sada smatrala stabilnim ( nepromjenjivim) markerom PB-i. Depresivni PB ispitanici imaju klinički zahvaćeniju nedominantnu stranu tijela što može poslužiti kao svojevrsni prediktor kasnije depresije u ranoj fazi bolesti. Iako je povišen broj patoloških nalaz SN u velikom depresivnom poremećaju taj je broj viši u PB-i što odgovara ranijim istraživanjima. Također je više patoloških nalaza SN kao i NL u skupini depresivnih PB prema skupini velikog depresivnog poremećaja dok razlike u nalazu NR nismo dokazali.
Dokazali smo korelaciju nalaza TCD-a sa stupnjem bolesti u depresivnoj podskupini PB-i što predstavlja novinu u odnosu na prethodne studije što svakako zahtijeva daljnja istraživanja.

Abstract (english)

Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's dementia.
With this study we emphasized the importance of the TCS in PD and premotor symptoms especially depression.
The hypothesis was that TCS of mesencephalic nuclei can distinguish patients with depression in PD from those without it as an early (nonmotor) sign of iPD.
Our research was conducted on 150 PD patients, 52 major depression patients, and 100 individuals without signs of iPD or depression.
TCS was performed once on Aloka prosound α-10 ultrasound. For disease severity in PD we used UPDRS and H&Y scales, and for depression BECK Depression Inventory Scale.
Our result showed a significant difference at the level of basal ganglia between PD patients with and without depression. We have established a correlation between the size of SN and BDI score (higher the BDI score, larger the size of SN). This result confronts all the studies so far because the size of SN was considered to be the stable marker of PD. Depressed PD patients have predominantly affected the nondominant side of the body that can stand as a predictor of depression later on as the disease progresses. We found more pathological findings of SN in major depression but this number is still higher in PD that correlates with earlier studies. We also found more pathological findings of SN and NL in depressed PD patients than in major depression, without difference in NR findings.
We have shown correlation between disease severity and TCS findings in depressed PD patients that confront with the majority of previous studies that demands further research.

• Keywords: Parkinsonova bolest; Depresija; Depresivni poremećaj; Alzheimerova bolest; Neurodegenerativne bolesti
• Keywords (english): Parkinson Disease; Depression; Depressive Disorder; Alzheimer Disease; Neurodegenerative Diseases
• Language: croatian
• URN:NBN: urn:nbn:hr:105:446074
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 75 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-11-11 09:06:35