Chondrocyte transplantation in treatment of the focal chondral lesions

master's thesis

• Title (croatian): Transplatacija hondrocita u liječenju oštećene zglobne hrskavice
• Author: Michael Markman
• Mentor: Mislav Jelić (mentor)
• Committee member: Mislav Jelić (predsjednik povjerenstva)
• Committee member: Domagoj Delimar (član povjerenstva)
• Committee member: Tomislav Đapić (član povjerenstva)
• Committee member: Marko Ajduk (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Orthopedics); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Orthopedics

Abstract

Focal chondral lesions are disruptions of the cartilaginous tissue in the body's joint that result in symptomatic knee lesions. The limited ability of the body to repair hyaline cartilage spontaneously, combined with the decreased quality of life of patients suffering from focal chondral lesions have led to development of surgical techniques that aim to repair the damaged chondral tissues and thus, restoring the patients quality of life. The purpose of this study is to review the technique of Autologous chondrocyte transplantation in the treatment of the focal chondral lesions together with the preoperative and postoperative procedures that accompany. Another aim of this study is the presentation of clinical outcomes that compare variations of autologous chondrocyte transplantation among themselves, and relative to other treatment modalities of the focal chondral lesions.

Abstract (croatian)

Žarišne hondralne lezije su poremećaji hrskavičnog tkiva u zglobu tijela koji rezultiraju simptomatskim lezijama koljena. Ograničena sposobnost tijela da spontano popravi hijalinsku hrskavicu, u kombinaciji sa smanjenom kvalitetom života pacijenata koji pate od žarišnih hondralnih lezija doveli su do razvoja kirurških tehnika kojima je cilj popravak oštećenih hondralnih tkiva, a time i obnavljanje kvalitete života pacijenata . Svrha ovog istraživanja je pregledati tehniku autologne transplantacije hondrocita u liječenju fokalnih hondralnih lezija zajedno s preoperativnim i postoperativnim postupcima koji prate. Sljedeći cilj ove studije je prikaz kliničkih ishoda koji uspoređuju varijacije autologne transplantacije hondrocita među
sobom i u odnosu na druge modalitete liječenja žarišnih hondralnih lezija.

• Keywords: focal chondral lesions; knee; cartilage; treatment; technique; autologous chondrocyte transplantation
• Keywords (croatian): žarišne hondralne lezije; koljeno; hrskavica; liječenje; tehnika; autologna transplantacija hondrocita
• Language: english
• URN:NBN: urn:nbn:hr:105:772121
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Public note: Pohranitelj objekta unio ključne riječi.
• Created on: 2021-12-22 11:27:53