Uloga nealkoholne masne bolesti jetre u bakterijskim infekcijama i sepsi

Scientific paper - Review paper

• Author: Juraj Krznarić
• Author: Maja Mijić
• Author: Ivana Štromar Knežević
• Author: Dora Šuk
• Author: Tajana Filipec Kanižaj
• Author: Adriana Vince
• Author: Neven Papić
• Author's institution: University of Zagreb; School of Medicine; (Department of Infectious Diseases)
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Infectology

Abstract (croatian)

Nealkoholna masna bolest jetre (engl. non-alcoholic fatty liver disease, NAFLD) najčešća je kronična bolest jetre, a povezana je sa sustavnim promjenama imunosnog odgovora koje potiču progresiju u nealkoholni steatohepatitis (NASH), cirozu jetre i razvoj hepatocelularnog karcinoma. Glavni rizični čimbenici za razvoj NAFLD-a jesu komponente metaboličkog sindroma, pretilost i šećerna bolest, koje su poznati rizični čimbenici za razvoj infekcija. Međutim, sve je više podataka o povezanosti NAFLD-a s bakterijskim infekcijama, neovisno o ostalim komponentama metaboličkog sindroma. Kod bolesnika s NAFLD-om opisane su češće rekurirajuće bakterijske infekcije, uroinfekcije, bakterijemije gastrointestinalnog ishodišta, enterokolitis Clostridoides difficile, kao i teža klinička slika i nepovoljni ishod pneumonije. Rastuća prevalencija NAFLD-a i NASH-a zahtjeva nove terapijske i profilaktičke pristupe bazirane na boljem razumijevanju imunopatogeneze bakterijskih infekcija u ovoj skupini bolesnika.

Abstract (english)

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease associated with
systemic changes in immune response that drives the progression to non-alcoholic steatohepatitis (NASH), liver
cirrhosis, and hepatocellular carcinoma (HCC). Major risk factors of NAFLD include obesity and type 2 diabetes
mellitus which are associated with infections. However, there is growing evidence that NAFLD is linked with
bacterial infections independently of other components of metabolic syndrome. Patients with NAFLD have been
described to have more common recurrent bacterial infections, urinary tract infections, bacteriemia of gastrointestinal origin, Clostridoides difficile enterocolitis, and more severe pneumonia. The rapidly increasing prevalence
of NAFLD and NASH require novel therapeutic and prophylactic approaches based on a better understanding of
immunopathogenesis of bacterial infections in these patients.

• Keywords (croatian): Deskriptori NEALKOHOLNA MASNA BOLEST JETRE – epidemiologija, imunologija, komplikacije; JETRA – imunologija; BAKTERIJSKE INFEKCIJE – epidemiologija, etiologija; SEPSA – epidemiologija, etiologija
• Keywords (english): NON-ALCOHOLIC FATTY LIVER DISEASE – complications, epidemiology, immunology; LIVER – immunology; BACTERIAL INFECTIONS – epidemiology, etiology; SEPSIS – epidemiology, etiology
• Language: croatian
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Liječnički vjesnik
• Numbering: vol. 143, no. 5-6, pp. 220-226
• p-ISSN: 0024-3477
• e-ISSN: 1849-2177
• DOI: https://doi.org/10.26800/LV-143-5-6-9
• URN:NBN: urn:nbn:hr:105:732963
• Publication: 2021
• Document URL: https://hrcak.srce.hr/260478
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-01-13 11:11:06