Optička koherentna tomografija u dijagnostici koronarne bolesti

master's thesis

• Title (english): Optical coherence tomography in the diagnosis of coronary artery disease
• Author: Ivona Adamović
• Mentor: Boško Skorić (mentor)
• Committee member: Joško Bulum (predsjednik povjerenstva)
• Committee member: Martina Lovrić Benčić (član povjerenstva)
• Committee member: Boško Skorić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Optička koherentna tomografija (OCT) jedna je od intravaskularnih metoda oslikavanja koronarnih arterija koja se koristi u dijagnostici koronarne bolesti. Primjena OCT-a u kardiologiji počela je 90-ih godina prošlog stoljeća, najviše u intervencijskoj kardiologiji kao nadopuna ostalim tehnikama oslikavanja, koronarografiji i intravaskularnom ultrazvuku. Ovo je metoda koja koristeći infracrvenu svjetlost, zbog svoje visoke rezolucije omogućuje jasno razlikovanje slojeva stijenke krvne žile uz detaljni prikaz morfologije aterosklerotskog plaka i intravaskularnih struktura. OCT omogućuje prepoznavanje različitih vrsta plakova, kao što su fibrozni plak, kalcificirani plak, te lezija s tankim fibroznim pokrovom. OCT omogućuje prikaz cijele cirkumferencije arterije, te lezija koje nije moguće vidjeti na klasičnoj koronarografiji (erozija, disekcija plaka) što je vrlo bitno kod evaluacije uzroka nastalog infarkta miokarda. Također, OCT omogućuje optimizaciju implantacije stenta te prilagodbu PCI strategije kod pojedinih pacijenata. Pomoću OCT-a moguće je preciznije odrediti potrebnu veličinu stenta, odnosno optimizirati rezultat prepoznavanjem neadekvatne ekspanzije i/ili apozicije stenta. Osim navedenog, OCT se može koristiti u pacijenata nakon transplantacije srca u dijagnostici koronarne vaskulopatije presatka, koja je česta komplikacija i jedna od ključnih uzroka zatajenja presatka.

Abstract (english)

Optical coherence tomography (OCT) is an intravascular imaging modality used in the diagnosis of coronary artery disease. The use of OCT in cardiology has started in the early 90s of the last century, mostly in intervention cardiology as a complementary imaging modality for coronary angiography and intravascular ultrasound. It uses infrared light and because of its high resolution allows a clear distinction of vessel wall layers and a detailed view of atherosclerotic plaque morphology and intravascular structures. OCT allows distinction between different types of plaques, such as fibrous plaque, calcified plaque, and thin cap fibroatheroma. It allows visualization of the whole arterial circumference, and also lesions that cannot be seen on the classic coronary angiography (plaque erosion, plaque dissection) which is very important in evaluating the cause of myocardial infarction. Also, OCT is useful in stent implantation optimization and adjusting the PCI strategy in different patients. With the help of OCT, it is possible to more precisely determine the required stent size for implantation and detect the inadequate expansion of the stent and/or stent position. After that, it is possible to optimize the result of stent implantation. Also, OCT can be used in patients after heart transplantation in the diagnosis of cardiac allograft vasculopathy, a common complication after transplantation and one of the most important causes of graft failure.

• Keywords: OCT; koronarna bolest; aterosklerotski plak; stent; koronarna vaskulopatija presatka
• Keywords (english): OCT; coronary artery disease; aterosclerotic plaque; stent; cardiac allograft vasculopathy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:661595
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-01-20 12:17:25