Intranazalna primjena inzulina kao terapijski pristup u liječenju Alzheimerove bolesti

master's thesis

• Title (english): Intranasal insulin as a therapeutic strategy in the treatment of Alzheimer's disease
• Author: Bruno Buljan
• Mentor: Melita Šalković-Petrišić (mentor)
• Committee member: Ninoslav Mimica (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Melita Šalković-Petrišić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pharmacology); Zagreb
• Defense date and country: 2021-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Pharmacology

Abstract

Alzheimerova bolest je neurodegeneraivna bolest sa značajnim ekonomskim i socijalnim učinkom na društvo. Do danas ne postoji sigurna teorija nastanka Alzheimerove bolesti niti značajno učinkovita terapija za Alzheimerovu bolest. Ovaj diplomski rad obrađuje mogućnosti intranazalne primjene inzulina kao potencijalnog budućeg terapijskog riješenja kroz tri dijela. U prvome dijelu je prikazana epidemiologija, klinička slika, patologija, patogeneza i odobrena terapija Alzheimerove bolesti; u drugome dijelu centralna inzulinska rezistencija kao moguća osnova patogeneze Alzheimerove bolesti i mehanicistički susptrat učinka intranazalno primjenjenog inzulina na razvoj i progresiju Alzheimerove bolesti; a u trećem dijelu pretklinička i klinička istraživanja intranazalne
primjene inzulina s porukom o učinkovitosti, sigurnosti i ograničenjima predložene terapije za Alzheimerovu bolest.

Abstract (english)

Alzheimer's disease is a neurodegenerative disease with a significant economic and social impact on society. To date, there is no reliable theory of Alzheimer's disease pathogenesis or significantly effective therapy for Alzheimer's disease. This thesis deals with the possibilities of intranasal administration of insulin as a potential future therapeutic solution through three parts. The first part presents the epidemiology, clinical picture, pathology, pathogenesis and approved therapy of Alzheimer's disease; in the second part, central insulin resistance as a possible basis for the pathogenesis of Alzheimer's disease and a mechanistic substrate of the effect of intranasally administered insulin on the development and progression of Alzheimer's disease is elaborated; and in the third part, preclinical and clinical studies of intranasal insulin administration are listed with a message about the efficacy, safety, and limitations of the proposed therapy for Alzheimer’s disease.

• Keywords: Alzheimerova bolest; inzulinska signalizacija; intranazalni inzulin; pretkliničke studije; kliničke studije
• Keywords (english): Alzheimer’s disease; insulin signalisation; intranasal insulin; preclinical studies; clinical studies
• Language: croatian
• URN:NBN: urn:nbn:hr:105:098193
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-01-28 11:37:29