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Scientific paper - Original scientific paper
The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder
Neuroscience Letters, 735 (2020); 135235. https://doi.org/10.1016/j.neulet.2020.135235
Havelka Meštrović, Ana; Tudor, Lucija; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Švob Štrac, Dubravka; Kovačić Petrović, Zrnka; Pivac, Nela

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Havelka Meštrović, A., Tudor, L., Nedić Erjavec, G., Nikolac Perković, M., Švob Štrac, D., Kovačić Petrović, Z. & Pivac, N. (2020). The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder. Neuroscience Letters, 735.. doi: 10.1016/j.neulet.2020.135235

Havelka Meštrović, Ana, et al. "The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder." Neuroscience Letters, vol. 735, 2020. https://doi.org/10.1016/j.neulet.2020.135235

Havelka Meštrović, Ana, Lucija Tudor, Gordana Nedić Erjavec, Matea Nikolac Perković, Dubravka Švob Štrac, Zrnka Kovačić Petrović and Nela Pivac. "The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder." Neuroscience Letters 735 (2020). https://doi.org/10.1016/j.neulet.2020.135235

Havelka Meštrović, A., et al. (2020) 'The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder', Neuroscience Letters, 735. doi: 10.1016/j.neulet.2020.135235

Havelka Meštrović A, Tudor L, Nedić Erjavec G, Nikolac Perković M, Švob Štrac D, Kovačić Petrović Z, and sur.. The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder. Neuroscience Letters [Internet]. 2020 September 14 [cited 2024 October 05];735. doi: 10.1016/j.neulet.2020.135235

A. Havelka Meštrović, et al., "The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder", Neuroscience Letters, vol. 735, September 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:163321. [Accessed: 05 October 2024]

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Metadata
Title (english)The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder
AuthorAna Havelka Meštrović
AuthorLucija Tudor
AuthorGordana Nedić Erjavec
AuthorMatea Nikolac Perković
AuthorDubravka Švob Štrac
AuthorZrnka Kovačić Petrović
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Posttraumatic stress disorder (PTSD) is a trauma-induced disorder characterized with impaired cognitive function. BDNF modulates cognition and is involved in neuroprotection and neurocognitive processing. The BDNF Val66Met polymorphism was found to influence cognitive functions. In PTSD, carriers of the BDNF GG genotype had better spatial processing of navigation performance, and lower hyperarousal and startle reaction than A allele carriers. The hypothesis was that veterans with PTSD, carriers of the BDNF Val66Met A allele, will show reduced cognitive skills. The study included 315 male Caucasian combat veterans, with (N = 199) or without (N = 116) current and chronic PTSD. Cognition was assessed using the Rey-Osterrieth Complex Figure (ROCF) test that determines visual-spatial perception and short and long-term visual memory function. The results revealed that cognitive decline measured with ROCF test was associated with PTSD. Presence of the BDNF Val66Met GG genotype in veterans with PTSD, but not in veterans without PTSD, showed protective association with visual short-term memory and visual object manipulation after few seconds (executive function), assessed with the ROCF immediate recall test, compared to the A carriers with PTSD. In conclusion, this was the first study to confirm the association between BDNF Val66Met and memory and attention performed with ROCF in male veterans with PTSD. The results corroborated that the BDNF Val66Met A allele, compared to GG genotype, is associated with poorer short-term visual memory and attention linked with executive functions, in veterans with PTSD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleNeuroscience Letters
Numberingvol. 735, 135235
p-ISSN0304-3940
e-ISSN1872-7972
DOIhttps://doi.org/10.1016/j.neulet.2020.135235
URN:NBNurn:nbn:hr:105:163321
Publication2020-09-14
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S030439402030505X
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-02-04 09:39:14