Domino transplantacija jetre

master's thesis

• Title (english): Domino liver transplantation
• Author: Mateo Krešić
• Mentor: Anna Mrzljak (mentor)
• Committee member: Lucija Virović Jukić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Anna Mrzljak (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Domino transplantacija jetre je postupak u kojem se eksplantirana jetra, osobe koja ima necirotičnu metaboličku jetrenu bolest, transplantira osobi s drugom jetrenom patologijom koja zahtijeva transplantaciju. Pacijent koji boluje od neke monogenske metaboličke bolesti jetre, kojoj je kurativna terapija transplantacija jetre, preuzima ulogu primatelja, a potom i darivatelja. Primatelj njegove eksplantirane jetre može biti osoba čiji se životni vijek smatra kraćim od očekivanog za nastup metaboličke bolesti zbog primitka takve jetre ili kao terapija premoštenja do definitivne terapije odnosno retransplantacije. Domino transplantacija jetre prvi put je izvedena u Portugalu 1995. godine kod osobe s obiteljskom amiloidnom polineuropatijom, a do danas su takvi zahvati izvedeni u 66 bolnica diljem svijeta na više od 1000 pacijenta. Dijagnoze darivatelja domino jetara proširile su se na aciduriju aminokiselina razgranatih lanaca, primarnu hiperoksaluriju, akutnu intermitentnu porfiriju, homozigotnu obiteljsku hiperkolesterolemiju, propionsku acidemiju, hiperhomocisteinemiju, hemofiliju A te mnoge druge. Prognoza nakon domino transplantacije jetre ovisi o brojnim čimbenicima, a među važnijima je osnovna jetrena bolest. Ovaj rad nudi sažet prikaz koncepta domino transplantacije, specifičnih indikacija, rizika te dosadašnjih rezultata.

Abstract (english)

Domino liver transplantation is a procedure in which an explanted liver, from a patient with non-cirrhotic metabolic liver disease, is transplanted to a person with a different liver pathology which requires transplantation. A patient suffering from a monogenic metabolic liver disease, for which liver transplantation is a curative therapy, takes on the role of both recipient and donor. The recipient of his explanted liver may be a person whose life expectancy is considered to be shorter than the expected time for the onset of the metabolic disease caused by reception of such a liver. It can also be used as bridging therapy until definitive therapy or retransplantation. Domino liver transplantation was first performed in Portugal in 1995 on a person with familial amyloid polyneuropathy, while today such procedures have been performed in 66 hospitals around the world on more than 1,000 patients. Diagnoses of domino liver donors have expanded to maple syrup urine disease, primary hyperoxaluria, acute intermittent porphyria, homozygous familial hypercholesterolemia, propionic acidemia, hyperhomocysteinemia, and hemophilia A. The prognosis after a domino liver transplantation depends on a number of factors, the most important among them being an underlying liver disease. This paper offers a summary of the concept of domino transplantation, specific indications, risks and results to date.

• Keywords: domino transplantacija jetre; acidurija aminokiselina razgranatih lanaca; obiteljska amiloidna polineuropatija; primarna hiperoksalurija
• Keywords (english): domino liver transplantation; maple syrup urine disease; familial amyloid polyneuropathy; primary hyperoxaluria
• Language: croatian
• URN:NBN: urn:nbn:hr:105:111157
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-25 10:54:16