Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes

Scientific paper - Original scientific paper

• Author: Michał Kukla
• Author: Tomasz Menżyk
• Author: Marcin Dembiński
• Author: Marek Winiarski
• Author: Aleksander Garlicki
• Author: Monika Bociąga-Jasik
• Author: Magdalena Skonieczna
• Author: Dorota Hudy
• Author: Barbara Maziarz
• Author: Beata Kusnierz-Cabala
• Author: Lubomir Skladany
• Author: Ivica Grgurević
• Author: Małgorzata Wójcik-Bugajska
• Author: Tomasz Grodzicki
• Author: Dominika Stygar
• Author: Tomasz Rogula
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (english)

Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation. A wide range of adipokines activities suggests they influence pathogenesis and infection course. The aim was to assess concentrations of chemerin, omentin, and vaspin among COVID-19 patients with an emphasis on adipokines relationship with COVID-19 severity, concomitant metabolic abnormalities and liver dysfunction. Serum chemerin, omentin and vaspin concentrations were measured in serum collected from 70 COVID-19 patients at the moment of admission to hospital, before any treatment was applied and 20 healthy controls. Serum chemerin and omentin concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers (271.0 vs. 373.0 ng/ml; p < 0.001 and 482.1 vs. 814.3 ng/ml; p = 0.01, respectively). There were no correlations of analyzed adipokines with COVID-19 severity based on the presence of pneumonia, dyspnea, or necessity of Intensive Care Unit hospitalization (ICU). Liver test abnormalities did not influence adipokines levels. Elevated GGT activity was associated with ICU admission, presence of pneumonia and elevated concentrations of CRP, ferritin and interleukin 6. Chemerin and omentin depletion in COVID-19 patients suggests that this adipokines deficiency play influential role in disease pathogenesis. However, there was no relationship between lower adipokines level and frequency of COVID-19 symptoms as well as disease severity. The only predictive factor which could predispose to a more severe COVID-19 course, including the presence of pneumonia and ICU hospitalization, was GGT activity.

• Keywords (english): Adipokines / blood*; Aged; Body Mass Index; C-Reactive Protein / analysis; COVID-19 / complications; COVID-19 / metabolism; COVID-19 / pathology; COVID-19 / virology; Case-Control Studies; Chemokines / blood*; Cytokines / blood*; Female; GPI-Linked Proteins / blood; Hospitalization; Humans; Lectins / blood*; Liver / metabolism; Male; Metabolic Syndrome / complications; Middle Aged; SARS-CoV-2 / isolation & purification; Serpins / blood*; gamma-Glutamyltransferase / metabolism
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Scientific Reports
• Numbering: vol. 11, no. 1, 21514
• e-ISSN: 2045-2322
• DOI: https://doi.org/10.1038/s41598-021-00928-w
• URN:NBN: urn:nbn:hr:105:283619
• Publication: 2021-11-02
• Document URL: https://www.nature.com/articles/s41598-021-00928-w
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-03-15 08:29:15