prikaz prve stranice dokumenta Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men
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Scientific paper - Original scientific paper
Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men
Life, 11 (2021), 9; 989. https://doi.org/10.3390/life11090989
Marić, Tihana; Katušić Bojanac, Ana; Matijević, Ana; Ceppi, Marcello; Bruzzone, Marco; Evgeni, Evangelini; Petrovic, Tea; Wójcik, Iwona; Trbojevic-Akmacic, Irena; Lauc, Gordan; Ježek, Davor; Fučić, Aleksandra

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Marić, T., Katušić Bojanac, A., Matijević, A., Ceppi, M., Bruzzone, M., Evgeni, E. ... Fučić, A. (2021). Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men. Life, 11. (9). doi: 10.3390/life11090989

Marić, Tihana, et al. "Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men." Life, vol. 11, no. 9, 2021. https://doi.org/10.3390/life11090989

Marić, Tihana, Ana Katušić Bojanac, Ana Matijević, Marcello Ceppi, Marco Bruzzone, Evangelini Evgeni, Tea Petrovic, et al. "Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men." Life 11, no. 9 (2021). https://doi.org/10.3390/life11090989

Marić, T., et al. (2021) 'Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men', Life, 11(9). doi: 10.3390/life11090989

Marić T, Katušić Bojanac A, Matijević A, Ceppi M, Bruzzone M, Evgeni E, and sur.. Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men. Life [Internet]. 2021 September 20 [cited 2024 October 10];11(9). doi: 10.3390/life11090989

T. Marić, et al., "Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men", Life, vol. 11, no. 9, September 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:076068. [Accessed: 10 October 2024]

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Metadata
Title (english)Seminal Plasma Protein N-Glycan Peaks Are Potential Predictors of Semen Pathology and Sperm Chromatin Maturity in Men
AuthorTihana Marić
AuthorAna Katušić Bojanac
AuthorAna Matijević
AuthorMarcello Ceppi
AuthorMarco Bruzzone
AuthorEvangelini Evgeni
AuthorTea Petrovic
AuthorIwona Wójcik
AuthorIrena Trbojevic-Akmacic
AuthorGordan Lauc
AuthorDavor Ježek
AuthorAleksandra Fučić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract (english)
Background: Male infertility is increasingly becoming a health and demographic problem. While it may originate from congenital or acquired diseases, it can also result from environmental exposure. Hence, the complexity of involved molecular mechanisms often requires a multiparametric approach. This study aimed to associate semen parameters with sperm DNA fragmentation, chromatin maturity and seminal plasma protein N-glycosylation. ----- Methods: The study was conducted with 166 participants, 20–55 y old, 82 normozoospermic and 84 with pathological diagnosis. Sperm was analyzed by Halosperm assay and aniline blue staining, while seminal plasma total protein N-glycans were analyzed by ultra-high-performance liquid chromatography. ----- Results: Sperm DNA fragmentation was significantly increased in the pathological group and was inversely correlated with sperm motility and viability. Seminal plasma total protein N-glycans were chromatographically separated in 37 individual peaks. The pattern of seminal plasma N-glycan peaks (SPGP) showed that SPGP14 significantly differs between men with normal and pathological semen parameters (p < 0.001). The multivariate analysis showed that when sperm chromatin maturity increases by 10%, SPGP17 decreases by 14% while SPGP25 increases by 25%. ----- Conclusion: DNA integrity and seminal plasma N-glycans are associated with pathological sperm parameters. Specific N-glycans are also associated with sperm chromatin maturity and have a potential in future fertility research and clinical diagnostics.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLife
Numberingvol. 11, no. 9, 989
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life11090989
URN:NBNurn:nbn:hr:105:076068
Publication2021-09-20
Document URLhttps://www.mdpi.com/2075-1729/11/9/989
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-04-21 07:30:35