Comparison of systemic inflammatory responses of proximal femoral nail versus dynamic hip screw after treatment of patients with pertrochanteric fractures: A prospective comparative study

Scientific paper - Original scientific paper

• Author: Kushtrim Grezda
• Author: Mislav Jelić
• Author: Armond Daci
• Author: Cen Bytyqi
• Author: Qerim Kida
• Author's institution: University of Zagreb; School of Medicine; (Department of Orthopedics)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Orthopedics

Abstract (english)

Objective: The aim of this study was to investigate the differences between the induction of early postoperative inflammatory response and muscle tissue injury biomarkers after treatment of pertrochanteric fractures by dynamic hip screw (DHS) or proximal femoral nail (PFN).

Methods: In this prospective comparative study, 40 patients with AO-Müller/Orthopaedic Trauma Association (AO/OTA) 31. A1-31.A2 pertrochanteric fractures were enrolled and allocated one of the two groups based on the treatment type: group DHS, (n =20,mean age = 78.4 ± 6.9 years) and group PFN (n = 20, mean age = 77.75 ± 7.0 years). Operation time was recorded in both groups. In each patient, circulating levels of high sensitivity interleukin-6 (hs-IL-6), C-reactive protein (CRP), and creatine kinase (CK), and erythrocyte sedimentation rate (ESR)weremeasured fromblood samples collected 1 hour preoperatively and 24 hours postoperatively.

Results: The operation time was slightly shorter in group PFN than in group DHS (51.9 ± 21.1 and 38 ± 15.2 min, respectively; P = 0.02). DHS and PFN both increased hs-IL-6 (143.81 ± 89.12 and 94.13 ± 67.14, respectively), CRP (98.84 ± 31.81 and 104.4 ± 31.80, respectively), and CK (400.8 ± 31.81 and 250.7 ± 31.80, respectively) 24 hours postoperatively. However, PFN compared to DHS resulted in a lesser increase from baseline to 24 hours postoperatively only in hs IL-6 (58.91 ± 59.02 vs 113.30 ± 76.24, respectively; P = 0.0016) and CK (163.6 ± 123.3 vs 310.0 ± 198.3, respectively; P < 0.0001).Moreover, there was a positive correlation of CK levels' surgery time in DHS (r = 0.38, P = 0.0065) and PFN (r = 0.45, P = 0.0013).

Conclusion: The results of this study have shown that PFN can induce a lower early postoperative inflammatory response and muscle tissue injury based on the assessment of hs-IL-6 and CK levels, compared to DHS in after the treatment patients pertrochanteric fractures.

• Keywords (english): Aged; Aged, 80 and over; Bone Nails; Bone Screws; Fracture Fixation, Intramedullary / adverse effects; Hip Fractures / surgery; Humans; Prospective Studies; Treatment Outcome
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Acta Orthopaedica et Traumatologica Turcica
• Numbering: vol. 55, no. 4, pp. 293-298
• p-ISSN: 1017-995X
• e-ISSN: 2589-1294
• DOI: https://doi.org/10.5152/j.aott.2021.20193
• URN:NBN: urn:nbn:hr:105:274943
• Publication: 2021-08
• Document URL: https://www.aott.org.tr/en/comparison-of-systemic-inflammatory-responses-of-proximal-femoral-nail-versus-dynamic-hip-screw-after-treatment-of-patients-with-pertrochanteric-fractures-a-prospective-comparative-study-137163
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-05-09 11:04:26