prikaz prve stranice dokumenta Genistein as a regulator of signaling pathways and microRNAs in different types of cancers
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Scientific paper - Review paper
Genistein as a regulator of signaling pathways and microRNAs in different types of cancers
Cancer Cell International, 21 (2021), 1; 388. https://doi.org/10.1186/s12935-021-02091-8
Javed, Zeeshan; Khan, Khushbukhat; Herrera-Bravo, Jesús; Naeem, Sajid; Iqbal, Muhammad Javed; Sadia, Haleema; Qadri, Qamar Raza; Raza, Shahid; Irshad, Asma; Akbar, Ali; Reiner, Željko; Al-Harrasi, Ahmed; Al-Rawahi, Ahmed; Satmbekova, Dinara; Butnariu, Monica; Bagiu, Iulia Cristina; Bagiu, Radu Vasile; Sharifi-Rad, Javad More authors...

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Javed, Z., Khan, K., Herrera Bravo, J., Naeem, S., Iqbal, M. J., Sadia, H. ... Sharifi Rad, J. (2021). Genistein as a regulator of signaling pathways and microRNAs in different types of cancers. Cancer Cell International, 21. (1). doi: 10.1186/s12935-021-02091-8

Javed, Zeeshan, et al. "Genistein as a regulator of signaling pathways and microRNAs in different types of cancers." Cancer Cell International, vol. 21, no. 1, 2021. https://doi.org/10.1186/s12935-021-02091-8

Javed, Zeeshan, Khushbukhat Khan, Jesús Herrera Bravo, Sajid Naeem, Muhammad Javed Iqbal, Haleema Sadia, Qamar Raza Qadri, et al. "Genistein as a regulator of signaling pathways and microRNAs in different types of cancers." Cancer Cell International 21, no. 1 (2021). https://doi.org/10.1186/s12935-021-02091-8

Javed, Z., et al. (2021) 'Genistein as a regulator of signaling pathways and microRNAs in different types of cancers', Cancer Cell International, 21(1). doi: 10.1186/s12935-021-02091-8

Javed Z, Khan K, Herrera Bravo J, Naeem S, Iqbal MJ, Sadia H, and sur.. Genistein as a regulator of signaling pathways and microRNAs in different types of cancers. Cancer Cell International [Internet]. 2021 July 21 [cited 2024 May 15];21(1). doi: 10.1186/s12935-021-02091-8

Z. Javed, et al., "Genistein as a regulator of signaling pathways and microRNAs in different types of cancers", Cancer Cell International, vol. 21, no. 1, July 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:385664. [Accessed: 15 May 2024]

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Metadata
Title (english)Genistein as a regulator of signaling pathways and microRNAs in different types of cancers
AuthorZeeshan Javed
AuthorKhushbukhat Khan
AuthorJesús Herrera-Bravo
AuthorSajid Naeem
AuthorMuhammad Javed Iqbal
AuthorHaleema Sadia
AuthorQamar Raza Qadri
AuthorShahid Raza
AuthorAsma Irshad
AuthorAli Akbar
AuthorŽeljko Reiner
AuthorAhmed Al-Harrasi
AuthorAhmed Al-Rawahi
AuthorDinara Satmbekova
AuthorMonica Butnariu
AuthorIulia Cristina Bagiu
AuthorRadu Vasile Bagiu
AuthorJavad Sharifi-Rad
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Recent advances in the field of next generation sequencing and functional genomics have brought us closer towards unravelling the complexities of tumor microenvironment (tumor heterogeneity) and deregulated signaling cascades responsible for proliferation and survival of tumor cells. Phytochemicals have begun to emerge as potent beneficial substances aimed to target deregulated signaling pathways. Isoflavonoid genistein is an essential phytochemical involved in regulation of key biological processes including those in different types of cancer. Emerging preclinical evidence have shown its anti-cancer, anti-inflammatory and anti-oxidant properties. Testing of this substance is in various phases of clinical trials. Comprehensive preclinical and clinical trials data is providing insight on genistein as a modulator of various signaling pathways both at transcription and translation levels. In this review we have explained the mechanistic regulation of several key cellular pathways by genistein. We have also addressed in detail various microRNAs regulated by genistein in different types of cancer. Moreover, application of nano-formulations to increase the efficiency of genistein is also discussed. Understanding the pleiotropic potential of genistein to regulate key cellular pathways and development of efficient drug delivery system will bring us a step towards designing better chemotherapeutics.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCancer Cell International
Numberingvol. 21, no. 1, 388
e-ISSN1475-2867
DOIhttps://doi.org/10.1186/s12935-021-02091-8
URN:NBNurn:nbn:hr:105:385664
Publication2021-07-21
Document URLhttps://cancerci.biomedcentral.com/articles/10.1186/s12935-021-02091-8
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-06-06 07:50:45