External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis

Gazda, Jakub; Janicko, Martin; Drazilova, Sylvia; Grgurević, Ivica; Filipec Kanižaj, Tajana; Koller, Tomas; Bodorovska, Beatrica; Mijić, Maja; Mikolašević, Ivana; Knežević Štromar, Ivana; Kucinsky, Branislav; Gazda, Matej; Jarcuska, Peter

doi:10.1155/2021/9928065

prikaz prve stranice dokumenta External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis

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Scientific paper - Original scientific paper

External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis

Canadian Journal of Gastroenterology and Hepatology, 2021 (2021); 9928065. https://doi.org/10.1155/2021/9928065

Gazda, Jakub; Janicko, Martin; Drazilova, Sylvia; Grgurević, Ivica; Filipec Kanižaj, Tajana; Koller, Tomas; Bodorovska, Beatrica; Mijić, Maja; Mikolašević, Ivana; Knežević Štromar, Ivana; Kucinsky, Branislav; Gazda, Matej; Jarcuska, Peter

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APA 6th Edition

Gazda, J., Janicko, M., Drazilova, S., Grgurević, I., Filipec Kanižaj, T., Koller, T. ... Jarcuska, P. (2021). External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis. Canadian Journal of Gastroenterology and Hepatology, 2021.. doi: 10.1155/2021/9928065

MLA 8th Edition

Gazda, Jakub, et al. "External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis." Canadian Journal of Gastroenterology and Hepatology, vol. 2021, 2021. https://doi.org/10.1155/2021/9928065

Chicago 17th Edition

Gazda, Jakub, Martin Janicko, Sylvia Drazilova, Ivica Grgurević, Tajana Filipec Kanižaj, Tomas Koller, Beatrica Bodorovska, et al. "External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis." Canadian Journal of Gastroenterology and Hepatology 2021 (2021). https://doi.org/10.1155/2021/9928065

Harvard

Gazda, J., et al. (2021) 'External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis', Canadian Journal of Gastroenterology and Hepatology, 2021. doi: 10.1155/2021/9928065

Vancouver

Gazda J, Janicko M, Drazilova S, Grgurević I, Filipec Kanižaj T, Koller T, and sur.. External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis. Canadian Journal of Gastroenterology and Hepatology [Internet]. 2021 June 22 [cited 2024 April 18];2021. doi: 10.1155/2021/9928065

IEEE

J. Gazda, et al., "External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis", Canadian Journal of Gastroenterology and Hepatology, vol. 2021, June 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:410443. [Accessed: 18 April 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:410443

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Metadata

Title (english)	External Validation of UDCA Response Score in Slovak and Croatian Patients with Primary Biliary Cholangitis
Author	Jakub Gazda
Author	Martin Janicko
Author	Sylvia Drazilova
Author	Ivica Grgurević
Author	Tajana Filipec Kanižaj
Author	Tomas Koller
Author	Beatrica Bodorovska
Author	Maja Mijić
Author	Ivana Mikolašević
Author	Ivana Knežević Štromar
Author	Branislav Kucinsky
Author	Matej Gazda
Author	Peter Jarcuska
Author's institution	University of Zagreb School of Medicine (Department of Internal Medicine)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Internal Medicine
Abstract (english)	Background: Ursodeoxycholic acid response score (URS) is a prognostic model that estimates the baseline probability of treatment response after 12 months of ursodeoxycholic acid (UDCA) therapy in patients with primary biliary cholangitis (PBC). ------ Aim: To independently evaluate the predictive performance of the URS model. ----- Methods: We used a cohort of Slovak and Croatian treatment-naïve PBC patients to quantify the discrimination ability using the area under receiver operating characteristic curve (AUROC) and its 95% confidence interval (CI). Furthermore, we evaluated the calibration using calibration belts. The primary outcome was treatment response after 12 months of UDCA therapy defined as values of alkaline phosphatase ≤1.67 × upper limit of normal. ----- Results: One hundred and ninety-four patients were included. Median pretreatment age was 56 years (interquartile range 49-62). Treatment response was achieved in 79.38% of patients. AUROC of the URS was 0.81 (95% CI 0.73-0.88) and the calibration belt revealed that response rates were correctly estimated by predicted probabilities. ----- Conclusion: Our results confirm that the URS can be used in treatment-naïve PBC patients for estimating the treatment response probability after 12 months of UDCA therapy.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Canadian Journal of Gastroenterology and Hepatology
Numbering	vol. 2021, 9928065
p-ISSN	2291-2789
e-ISSN	2291-2797
DOI	https://doi.org/10.1155/2021/9928065
URN:NBN	urn:nbn:hr:105:410443
Publication	2021-06-22
Document URL	https://www.hindawi.com/journals/cjgh/2021/9928065/
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2022-06-09 07:32:29