prikaz prve stranice dokumenta Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance
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Scientific paper - Original scientific paper
Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance
Progress in Orthodontics, 22 (2021), 1; 19. https://doi.org/10.1186/s40510-021-00364-6
Grgurević, Lovorka; Novak, Ruđer; Salai, Grgur; Trkulja, Vladimir; Ferhatovicć Hamzić, Lejla; Zgombić Popović, Vojka; Božić, Darko

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Grgurević, L., Novak, R., Salai, G., Trkulja, V., Ferhatovicć Hamzić, L., Zgombić Popović, V. & Božić, D. (2021). Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance. Progress in Orthodontics, 22. (1). doi: 10.1186/s40510-021-00364-6

Grgurević, Lovorka, et al. "Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance." Progress in Orthodontics, vol. 22, no. 1, 2021. https://doi.org/10.1186/s40510-021-00364-6

Grgurević, Lovorka, Ruđer Novak, Grgur Salai, Vladimir Trkulja, Lejla Ferhatovicć Hamzić, Vojka Zgombić Popović and Darko Božić. "Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance." Progress in Orthodontics 22, no. 1 (2021). https://doi.org/10.1186/s40510-021-00364-6

Grgurević, L., et al. (2021) 'Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance', Progress in Orthodontics, 22(1). doi: 10.1186/s40510-021-00364-6

Grgurević L, Novak R, Salai G, Trkulja V, Ferhatovicć Hamzić L, Zgombić Popović V, and sur.. Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance. Progress in Orthodontics [Internet]. 2021 July 12 [cited 2024 November 07];22(1). doi: 10.1186/s40510-021-00364-6

L. Grgurević, et al., "Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance", Progress in Orthodontics, vol. 22, no. 1, July 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:004196. [Accessed: 07 November 2024]

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Metadata
Title (english)Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance
AuthorLovorka Grgurević
AuthorRuđer Novak
AuthorGrgur Salai
AuthorVladimir Trkulja
AuthorLejla Ferhatovicć Hamzić
AuthorVojka Zgombić Popović
AuthorDarko Božić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
Background: This study was conducted in order to explore the effects of orthodontic tooth movement (OTM) on the changes of salivary proteome. This prospective observational pilot study recruited 12 healthy teenage boys with malocclusion treated with a fixed orthodontic appliance and 6 appropriate control participants. Saliva samples were collected a day before and at 0, 2, 7, and 30 days after initialization of treatment, corresponding to the initial, lag, and post-lag phases of OTM. Pooled samples were analyzed by liquid chromatography-mass spectrometry, ELISA, and Western blotting. To date, there is no published data on the presence of BMP molecules or their antagonists in the saliva or in the gingival cervical fluid related to orthodontic conditions. ----- Results: A total of 198 identified saliva proteins were classified based on their functional characteristics. Proteins involved in bone remodeling were observed exclusively 30 days post appliance placement, including bone morphogenetic protein 4 (BMP4), a BMP antagonist BMP-binding endothelial regulator, insulin-like growth factor-binding protein 3, cytoskeleton-associated protein 4, and fibroblast growth factor 5. Based on the analysis of protein interactions, BMP4 was found to have a central position in this OTM-related protein network. ----- Conclusions: The placement of a fixed orthodontic appliance induced occurrence of proteins involved in bone remodeling in the saliva at a time corresponding to the post-lag period of OTM. Limitations of this study include a relatively small sample size, limited time of monitoring patients, and the lack of interindividual variability assessment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleProgress in Orthodontics
Numberingvol. 22, no. 1, 19
e-ISSN2196-1042
DOIhttps://doi.org/10.1186/s40510-021-00364-6
URN:NBNurn:nbn:hr:105:004196
Publication2021-07-12
ProjectNumber: KK.01.1.1.01.0008
Title (croatian): Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platformi i potencijala
Acronym: CERRM
Leader: Slobodan Vukičević
Jurisdiction: eu
Document URLhttps://progressinorthodontics.springeropen.com/articles/10.1186/s40510-021-00364-6
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-06-09 07:39:37