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Scientific paper - Original scientific paper
Nonalcoholic Fatty Liver Disease—A Novel Risk Factor for Recurrent Clostridioides difficile Infection
Antibiotics, 10 (2021), 7; 780. https://doi.org/10.3390/antibiotics10070780
Šamadan, Lara; Jeličić, Mia; Vince, Adriana; Papić, Neven

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Šamadan, L., Jeličić, M., Vince, A. & Papić, N. (2021). Nonalcoholic Fatty Liver Disease—A Novel Risk Factor for Recurrent Clostridioides difficile Infection. Antibiotics, 10. (7). doi: 10.3390/antibiotics10070780

Šamadan, Lara, et al. "Nonalcoholic Fatty Liver Disease—A Novel Risk Factor for Recurrent Clostridioides difficile Infection." Antibiotics, vol. 10, no. 7, 2021. https://doi.org/10.3390/antibiotics10070780

Šamadan, Lara, Mia Jeličić, Adriana Vince and Neven Papić. "Nonalcoholic Fatty Liver Disease—A Novel Risk Factor for Recurrent Clostridioides difficile Infection." Antibiotics 10, no. 7 (2021). https://doi.org/10.3390/antibiotics10070780

Šamadan, L., et al. (2021) 'Nonalcoholic Fatty Liver Disease—A Novel Risk Factor for Recurrent Clostridioides difficile Infection', Antibiotics, 10(7). doi: 10.3390/antibiotics10070780

Šamadan L, Jeličić M, Vince A, Papić N. Nonalcoholic Fatty Liver Disease—A Novel Risk Factor for Recurrent Clostridioides difficile Infection. Antibiotics [Internet]. 2021 June 27 [cited 2024 December 07];10(7). doi: 10.3390/antibiotics10070780

L. Šamadan, M. Jeličić, A. Vince and N. Papić, "Nonalcoholic Fatty Liver Disease—A Novel Risk Factor for Recurrent Clostridioides difficile Infection", Antibiotics, vol. 10, no. 7, June 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:748382. [Accessed: 07 December 2024]

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Metadata
Title (english)Nonalcoholic Fatty Liver Disease—A Novel Risk Factor for Recurrent Clostridioides difficile Infection
AuthorLara Šamadan
AuthorMia Jeličić
AuthorAdriana Vince
AuthorNeven Papić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
Recurrent Clostridioides difficile infections (rCDI) have a substantial impact on healthcare systems, with limited and often expensive therapeutic options. Nonalcoholic fatty liver disease (NAFLD) affects about 25% of the adult population and is associated with metabolic syndrome, changes in gut microbiome and bile acids biosynthesis, all possibly related with rCDI. The aim of this study was to determine whether NAFLD is a risk factor associated with rCDI. A retrospective cohort study included patients ≥ 60 years hospitalized with CDI. The cohort was divided into two groups: those who were and were not readmitted with CDI within 3 months of discharge. Of the 329 patients included, 107 patients (32.5%) experienced rCDI. Patients with rCDI were older, had higher Charlson Age–Comorbidity Index (CACI) and were more frequently hospitalized within 3 months. Except for chronic kidney disease and NAFLD, which were more frequent in the rCDI group, there were no differences in other comorbidities, antibiotic classes used and duration of antimicrobial therapy. Multivariable Cox regression analysis showed that age >75 years, NAFLD, CACI >6, chronic kidney disease, statins and immobility were associated with rCDI. In conclusion, our study identified NAFLD as a possible new host-related risk factor associated with rCDI.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAntibiotics
Numberingvol. 10, no. 7, 780
e-ISSN2079-6382
DOIhttps://doi.org/10.3390/antibiotics10070780
URN:NBNurn:nbn:hr:105:748382
Publication2021-06-27
ProjectNumber: UIP-2019-04-7194
Title (croatian): Uloga imunih semaforina u nealkoholnoj masnoj bolesti jetre i sepsi
Title (english): The role of immune semaphorins in NAFLD and sepsis
Acronym: SepsisFAT
Leader: Neven Papić
Jurisdiction: Croatia
Funding stream: UIP
Document URLhttps://www.mdpi.com/2079-6382/10/7/780
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-06-15 12:11:46