Impact of preoperative antibiotic use in preventing complications of cochlear implantation surgery

Scientific paper - Original scientific paper

• Author: Andro Košec
• Author: Josipa Živko
• Author: Stela Marković
• Author: Vladimir Bedeković
• Author: Mihael Ries
• Author: Jakov Ajduk
• Author's institution: University of Zagreb; School of Medicine; (Department of Othorhinolaryngology and Head and Neck Surgery)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract (english)

Objective: To examine the impact of preoperative antibiotic prophylaxis on the occurrence of postoperative complications.
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Materials and methods: Data of 491 patients undergoing cochlear implantation were included in a non-randomized retrospective comparative cohort study. Demographic data, cochlear implant and surgical details, use of preoperative antibiotics and occurrence of postoperative complications were analyzed using a binary logistic regression model.
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Results: There were 317 patients (64.56%) who did not receive preoperative antibiotic prophylaxis and 174 (35.44%) patients who received preoperative antibiotic prophylaxis with ceftriaxone. The overall rate of complications requiring surgical treatment was 2.85%. Younger patient age was identified as a positive predictive factor for administering preoperative antibiotic prophylaxis (p<0.001, OR 1.05 CI 95% 1.0124-1.0826). No difference in complication rate was observed between the two groups. No correlation between sex, age, manufacturer, surgeon and postoperative complications were noted (p=0.45).
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Conclusion: There is insufficient evidence to inform decision making regarding preoperative intravenous ceftriaxone use for prevention of infection after cochlear implantation surgery, with data failing to show that administration of preoperative antibiotics leads to a decrease in complication rate. Considering a very low overall complication rate, with few complications related to infection, routine use of preoperative antibiotic prophylaxis should be analyzed further.

• Keywords (english): Anti-Bacterial Agents / therapeutic use; Ceftriaxone / therapeutic use; Cochlear Implantation / adverse effects; Cohort Studies; Humans; Postoperative Complications / etiology; Postoperative Complications / prevention & control; Retrospective Studies; Surgical Wound Infection / prevention & control
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Cochlear Implants International
• Numbering: vol. 23, no. 3, pp. 134-138
• p-ISSN: 1467-0100
• e-ISSN: 1754-7628
• DOI: https://doi.org/10.1080/14670100.2021.2013586
• URN:NBN: urn:nbn:hr:105:375063
• Publication: 2022-05
• Document URL: https://www.tandfonline.com/doi/full/10.1080/14670100.2021.2013586
• Type of resource: Text
• Access conditions: Open access; Embargo expiration date: 2023-06-01
• Created on: 2022-06-27 09:10:52