prikaz prve stranice dokumenta Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography
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Scientific paper - Original scientific paper
Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography
Digestive Diseases and Sciences, 67 (2022), 7; 3327-3332. https://doi.org/10.1007/s10620-021-07277-8
Podrug, Kristian; Trkulja, Vladimir; Zelenika, Marko; Bokun, Tomislav; Madir, Anita; Filipec Kanižaj, Tajana; O’Beirne, James; Grgurević, Ivica

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Podrug, K., Trkulja, V., Zelenika, M., Bokun, T., Madir, A., Filipec Kanižaj, T. ... Grgurević, I. (2022). Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography. Digestive Diseases and Sciences, 67. (7), 3327-3332. doi: 10.1007/s10620-021-07277-8

Podrug, Kristian, et al. "Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography." Digestive Diseases and Sciences, vol. 67, no. 7, 2022, pp. 3327-3332. https://doi.org/10.1007/s10620-021-07277-8

Podrug, Kristian, Vladimir Trkulja, Marko Zelenika, Tomislav Bokun, Anita Madir, Tajana Filipec Kanižaj, James O’Beirne and Ivica Grgurević. "Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography." Digestive Diseases and Sciences 67, no. 7 (2022): 3327-3332. https://doi.org/10.1007/s10620-021-07277-8

Podrug, K., et al. (2022) 'Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography', Digestive Diseases and Sciences, 67(7), pp. 3327-3332. doi: 10.1007/s10620-021-07277-8

Podrug K, Trkulja V, Zelenika M, Bokun T, Madir A, Filipec Kanižaj T, and sur.. Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography. Digestive Diseases and Sciences [Internet]. 2022 July [cited 2024 April 11];67(7):3327-3332. doi: 10.1007/s10620-021-07277-8

K. Podrug, et al., "Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography", Digestive Diseases and Sciences, vol. 67, no. 7, pp. 3327-3332, July 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:387531. [Accessed: 11 April 2024]

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Metadata
Title (english)Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography
AuthorKristian Podrug
AuthorVladimir Trkulja
AuthorMarko Zelenika
AuthorTomislav Bokun
AuthorAnita Madir
AuthorTajana Filipec Kanižaj
AuthorJames O’Beirne
AuthorIvica Grgurević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Background and aims: We aimed to validate newly proposed noninvasive criteria for diagnosing clinically significant portal hypertension (CSPH) using liver stiffness measurements (LSM) by transient elastography (TE) and platelet count. ----- Methods: Diagnostic performance of these new criteria for CSPH (LSM ≥ 25 kPa to rule in and Plt ≥ 150 × 109/L + LSM ≤ 15 kPa to rule out CSPH) were retrospectively tested in an independent cohort of consecutive patients who underwent hepatic venous pressure gradient (HVPG) measurements and liver biopsy due to suspicion of compensated advanced chronic liver disease. Suspicion of cACLD was based on LSM ≥ 10 kPa by TE or results of liver imaging, without overt signs of CSPH. Patients with conditions known to affect results of LSM (ALT > 5 × ULN, liver congestion, extrahepatic biliary obstruction, infiltrative liver neoplasms) were excluded. ----- Results: Seventy six (76) patients were included: 78.9% males, mean age 62 years, 36.8% suffered from alcoholic, 30.3% nonalcoholic fatty liver disease, 14.5% chronic viral hepatitis, 30.3% were obese, 52.6% had HVPG ≥ 10 mmHg, 56.6% had platelet count ≥ 150 × 109/L. LSM ≥ 25 kPa had 88.9% specificity (95% CI 73.9-96.9) to rule in, whereas Plt ≥ 150 + LSM ≤ 15 kPa had 100% sensitivity (95% CI 91.1-100) to rule out CSPH. ----- Conclusion: By using these simple noninvasive criteria 49/76 (64.5%) patients could be classified correctly for the presence/absence of CSPH, thus obviating the need for HVPG measurements.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleDigestive Diseases and Sciences
Numberingvol. 67, no. 7, pp. 3327-3332
p-ISSN0163-2116
e-ISSN1573-2568
DOIhttps://doi.org/10.1007/s10620-021-07277-8
URN:NBNurn:nbn:hr:105:387531
Publication2022-07
Document URLhttps://link.springer.com/10.1007/s10620-021-07277-8
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-06-28 07:03:28