Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements

Scientific paper - Review paper

• Author: Dinko Mitrečić
• Author: Valentina Hribljan
• Author: Denis Jagečić
• Author: Jasmina Isaković
• Author: Federica Lamberto
• Author: Alex Horánszky
• Author: Melinda Zana
• Author: Gabor Foldes
• Author: Barbara Zavan
• Author: Augustas Pivoriūnas
• Author: Salvador Martinez
• Author: Letizia Mazzini
• Author: Lidija Radenovic
• Author: Jelena Milasin
• Author: Juan Carlos Chachques
• Author: Leonora Buzanska
• Author: Min Suk Song
• Author: András Dinnyés
• Author's institution: University of Zagreb; School of Medicine; (Department of Histology and Embryology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Cytology, Histology and Embryology

Abstract (english)

From the first success in cultivation of cells in vitro, it became clear that developing cell and/or tissue specific cultures would open a myriad of new opportunities for medical research. Expertise in various in vitro models has been developing over decades, so nowadays we benefit from highly specific in vitro systems imitating every organ of the human body. Moreover, obtaining sufficient number of standardized cells allows for cell transplantation approach with the goal of improving the regeneration of injured/disease affected tissue. However, different cell types bring different needs and place various types of hurdles on the path of regenerative neurology and regenerative cardiology. In this review, written by European experts gathered in Cost European action dedicated to neurology and cardiology-Bioneca, we present the experience acquired by working on two rather different organs: the brain and the heart. When taken into account that diseases of these two organs, mostly ischemic in their nature (stroke and heart infarction), bring by far the largest burden of the medical systems around Europe, it is not surprising that in vitro models of nervous and heart muscle tissue were in the focus of biomedical research in the last decades. In this review we describe and discuss hurdles which still impair further progress of regenerative neurology and cardiology and we detect those ones which are common to both fields and some, which are field-specific. With the goal to elucidate strategies which might be shared between regenerative neurology and cardiology we discuss methodological solutions which can help each of the fields to accelerate their development.

• Keywords (english): Animals; Brain / anatomy & histology; Brain / metabolism; Brain Diseases / diagnosis; Brain Diseases / etiology; Brain Diseases / therapy; Cell Differentiation; Cell- and Tissue-Based Therapy; Disease Management; Extracellular Vesicles / metabolism; Guided Tissue Regeneration / methods; Heart Diseases / diagnosis; Heart Diseases / etiology; Heart Diseases / therapy; Humans; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; Myocardium; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Nerve Regeneration; Neurons / cytology; Neurons / metabolism; Organoids; Regenerative Medicine / methods; Stem Cell Transplantation / adverse effects; Stem Cell Transplantation / methods; Stem Cells / cytology; Stem Cells / metabolism
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: International Journal of Molecular Sciences
• Numbering: vol. 23, no. 2, 855
• e-ISSN: 1422-0067
• DOI: https://doi.org/10.3390/ijms23020855
• URN:NBN: urn:nbn:hr:105:463848
• Publication: 2022-01-13
• Document URL: https://www.mdpi.com/1422-0067/23/2/855
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-06-30 10:37:20