Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases

Scientific paper - Review paper

• Author: Atena Mansouri
• Author: Željko Reiner
• Author: Massimiliano Ruscica
• Author: Eugenia Tedeschi-Reiner
• Author: Shabnam Radbakhsh
• Author: Mariam Bagheri Ekta
• Author: Amirhossein Sahebkar
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (english)

Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades. Antioxidant and anti-inflammatory properties which are independent of the lipid-lowering effects of statins, i.e., their pleiotropic effects, might be beneficial in the prevention or treatment of many diseases. This review discusses the antioxidant effects of statins achieved by modulating the nuclear factor erythroid 2 related factor 2/ heme oxygenase-1 (Nrf2/HO-1) pathway in different organs and diseases. Nrf2 and other proteins involved in the Nrf2/HO-1 signaling pathway have a crucial role in cellular responses to oxidative stress, which is a risk factor for ASCVD. Statins can significantly increase the DNA-binding activity of Nrf2 and induce the expression of its target genes, such as HO-1 and glutathione peroxidase) GPx, (thus protecting the cells against oxidative stress. Antioxidant and anti-inflammatory properties of statins, which are independent of their lipid-lowering effects, could be partly explained by the modulation of the Nrf2/HO-1 pathway.

• Keywords (english): HO-1; Nrf2; anti-inflammation; antioxidants; statins
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Journal of Clinical Medicine
• Numbering: vol. 11, no. 5, 1313
• e-ISSN: 2077-0383
• DOI: https://doi.org/10.3390/jcm11051313
• URN:NBN: urn:nbn:hr:105:592076
• Publication: 2022-02-27
• Document URL: https://www.mdpi.com/2077-0383/11/5/1313
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-10-05 09:14:56