Title Secondary Parkinsonism Title (croatian) Sekundarni parkinsonizam Author Kilian Felix Wieland Mentor Srđana Telarović (mentor)Committee member Srđana Telarović (predsjednik povjerenstva)Committee member Zdravka Poljaković-Skurić (član povjerenstva)Committee member Mario Habek (član povjerenstva)Granter University of Zagreb Defense date and country 2021-11-16, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Parkinson’s Disease is the second most prevalent neurodegenerative disorder after Alzheimer’s. In the context of an aging population, the incidence rates are set to rise even more. At the same time, Parkinson’s Disease is a highly heterogeneous disorder, a real challenge in diagnosis and treatment. First mentioned in 1817, it is defined by the classical triad of resting tremor, bradykinesia, and rigidity. Besides the primary, idiopathic Parkinson’s Disease, different atypical parkinsonian syndromes and numerous secondary causes have been identified. In this review, we focused primarily on the secondary etiologies of parkinsonism, which are both a challenge and a chance for efficient treatment of Parkinson’s Disease. The most prevalent secondary etiologies include vascular, drug-induced parkinsonism, tumors, neuroinflammation, and metabolic dysregulation. We discussed the features that help identify and differentiate each entity and showed points for further research. In the context of current exclusively symptomatic treatment of parkinsonism with dopaminergic therapy, identifying underlying, treatable causes is extremely important. Neuroimaging is the diagnostic modality of choice since most etiologies of secondary parkinsonism show specific changes on magnetic resonance imaging scans. Furthermore, investigating the pathophysiologic processes of the etiologies of secondary parkinsonism could help understand the disease progression and show possible treatment strategies in future research.
Abstract (croatian) Parkinsonova bolest je drugi najrašireniji neurodegenerativni poremećaj nakon Alzheimerove bolesti. U kontekstu sve većeg starenja stanovništva, incidencija bolesti još više raste. U isto vrijeme, Parkinsonova bolest je visoko heterogeni poremećaj, a samim time i veliki izazov u dijagnozi i liječenju. Prvi puta opisana 1817. Godine, definirana je klasičnom trijadom tremora, bradikinezije i ukočenosti. Osim primarne, idiopatske Parkinsonove bolesti, identificirani su različiti atipični parkinsonijski sindromi i brojni sekundarni uzroci. U ovom smo se pregledu usredotočili prvenstveno na sekundarne etiologije parkinsonizma, koje su i izazov i prilika za učinkovito ralikovanje, a samim time I liječenje Parkinsonove bolesti. Najčešći sekundarne uzroci uključuju vaskularni, lijekovima-inducirani parkinsonizam, tumore, upalne bolesti središnjeg živčanog sustava i metaboličku disregulaciju. Razmatrane su značajke koje pomažu u prepoznavanju i razlikovanju svakog entiteta i prikazani su ciljevi za daljnja istraživanja. U kontekstu trenutnog, isključivo simptomatskog liječenja parkinsonizma dopaminergičkom terapijom, identificiranje primarnih, a time I lječivih uzroka je izuzetno važno. Slikovne pretrage mozga su dijagnostička metoda izbora, jer većina uzroka sekundarnog parkinsonizma pokazuje specifične promjene na skeniranju magnetskom rezonancijom. Nadalje, istraživanje patofizioloških procesa etiologije sekundarnog parkinsonizma moglo bi pomoći u razumijevanju napredovanja bolesti i pokazivanju mogućih strategija liječenja u budućim istraživanjima.
Keywords
Parkinson Disease
Hypokinesia
Tremor
Parkinsonian Disorders
Neurodegenerative Diseases
Keywords (croatian)
Parkinsonova bolest
Hipokinezija
Tremor
Parkinsonovi poremećaji
Neurodegenerativne bolesti
Language english URN:NBN urn:nbn:hr:105:136336 Study programme Title: Medicine (in English language) Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2022-12-29 09:35:24
