Karcinom gušterače

master's thesis

• Title (english): Pancreatic cancer
• Author: Jelena Cipek Pedić
• Mentor: Davor Hrabar (mentor)
• Committee member: Lucija Virović Jukić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Davor Hrabar (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2022-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Karcinom gušterače trenutačno je 12. najčešći karcinom u svijetu i prema projekcijama
do 2030. trebao bi postati drugi najčešći uzrok smrti od karcinoma općenito. Većina
oboljelih stariji su od 55 godina. Neki od čimbenika rizika za razvoj ovog karcinoma su
pušenje, konzumacija alkohola, kronični pankreatitis, pozitivna obiteljska anamneza i
dijabetes. Simptomi se javljaju kasno i nespecifični su, zbog čega se bolest često
otkriva tek u uznapredovaloj fazi. Kao inicijalna pretraga zbog dostupnosti,
neinvazivnosti i niskih troškova koristi se transabdominalni ultrazvuk. U slučaju
pozitivnog nalaza oboljeli se upućuju na CT koji se koristi i za procjenu stadija bolesti.
Procjena stadija prema TNM klasifikaciji najvažniji je korak u odabiru liječenja. Jedina
kurabilna metoda je potpuna kirurška resekcija karcinoma. Praćenje bolesnika nakon
resekcije i eventualno provedene kemoterapije ima za cilj pravodobno otkrivanje
recidiva kako bi se oboljelima mogle pružiti terapijske opcije sa što povoljnijim
ishodom. U slučaju neresektabilnih karcinoma provodi se palijativna skrb u cilju
postizanja što bolje kvalitete života i produljenja preživljenja.

Abstract (english)

Pancreatic cancer is currently the 12th most common cancer in the world. According to
projections, by 2030 it should become the second most common cause of cancer death
in general. Majority of the patients are older than 55 years. Common risk factors for
the development of this cancer are smoking, alcohol consumption, chronic pancreatitis,
positive family history and diabetes. The disease is often discovered in an advanced
stage due to late and non-specific symptoms. Transabdominal ultrasound is used as
an initial examination due to availability, non-invasiveness, and low costs. In the case
of a pathological finding, patients undergo a CT scan, which is also used to assess the
stage of the disease. Stage assessment performed according to the TNM classification
is a crucial step in the selection of treatment. The only curable method is complete
surgical resection of the cancer. Patient follow-up after resection and chemotherapy is
needed for timely detection of recurrence so that patients can be offered therapeutic
options with the most favourable outcome. For unresectable cancers, palliative care is
provided to achieve the best possible quality of life and prolong survival.

• Keywords: karcinom gušterače; dijagnostika; kirurško liječenje; radioterapija; kemoterapija; palijativna terapija
• Keywords (english): pancreatic cancer; diagnostics; surgical treatment; radiotherapy; chemotherapy; palliative care
• Language: croatian
• URN:NBN: urn:nbn:hr:105:989887
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-04 10:59:20