Stanični i krvni pripravci kao metode liječenja u ortobiologiji

master's thesis

• Title (english): Cellular and blood preparation as methods of treatment in orthobiology
• Author: Dinko Ezgeta
• Mentor: Alan Ivković (mentor)
• Committee member: Mislav Jelić (predsjednik povjerenstva)
• Committee member: Tomislav Đapić (član povjerenstva)
• Committee member: Alan Ivković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Orthopedics); Zagreb
• Defense date and country: 2022-09-02, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Orthopedics

Abstract

Ortobiologija relativno je nova metoda liječenja mišićno-koštanih bolesti. Postoje razni pripravci koji se danas mogu ubrajati u ovu skupinu i velika većina ih još uvijek nije u potpunosti standardizirana. Pripravci se mogu podijeliti na dvije velike skupine: krvne i stanične pripravke. Sami se pripravci mogu koristiti samostalno, no ponekad se koriste i u kombinaciji jedni s drugima sa ciljem sinergističkog djelovanja. Njihovo potencijalno ubrzavanje bioloških procesa zarastanja rana i regenerativno djelovanje mogli bi biti vrlo važni u pristupu liječenja mnogih mišićno-koštanih patoloških stanja. Neki od najproučavanijih pripravaka su plazma bogata trombocitima (PRP) i mezenhimalne matične stanice (MSC) dobivene iz različitih tkiva. Fokus ovog preglednog rada su klinička istraživanja vezana uz primjenu PRP-a, autolognog kondicioniranog seruma, koncentrata aspirata koštane srži i adipozno dobivenih matičnih stanica u liječenju ortopedskih stanja. Rezultati brojnih istraživanja oprečno su podijeljeni o utjecaju bioloških pripravaka. Velika raznovrsnost rezultata mogla bi se pripisati i varijabilnosti sastava pojedinih pripravaka, što dodatno otežava shvaćanje njihovih utjecaja na određena klinička stanja. Potrebna su daljnja visokokvalitetna randomizirana istraživanja kako bi bolje shvatili njihov utjecaj na bolesti.

Abstract (english)

Orthobiology is a relatively new treatment method in the treatment of musculoskeletal diseases. Various preparations on the market can be included in this group today, and most of the preparations are still not fully standardized. In general, preparations can be divided into two large groups: blood and cell-derived preparations. The preparations can be used independently, but sometimes they are used in combination with each other with the aim of synergistic action. Their potential enhancement of the biological processes of wound healing and regeneration could be significant in treating many musculoskeletal pathological conditions. The most studied preparations are platelet-rich plasma (PRP), and mesenchymal stem cells (MSC) obtained from various tissues. This review focused on clinical studies related to PRP, autologous conditioned serum, bone marrow aspirate concentrate, and adipose-derived stem cells. The results of numerous studies have been shared with different results of biological preparations. The wide variety of results could also be attributed to the variability of individual preparations' composition, making it even more challenging to understand their effects on specific clinical conditions. Further high-quality randomized trials are needed to understand their impact on musculoskeletal diseases.

• Keywords: ADSC; ASC; BMAC; Ortobiologija; PRP
• Keywords (english): ADSC; ASC; BMAC; Ortobiology; PRP
• Language: croatian
• URN:NBN: urn:nbn:hr:105:117263
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-09 08:12:54