Uloga nanotehnologije u liječenju i dijagnostici zloćudnih tumora

master's thesis

• Title (english): The role of nanotechnology in the treatment and diagnosis of malignant tumors
• Author: Ema Gudelj
• Mentor: Nikola Đaković (mentor)
• Committee member: Lidija Beketić-Orešković (predsjednik povjerenstva)
• Committee member: Jasmina Marić Brozić (član povjerenstva)
• Committee member: Nikola Đaković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Clinical Oncology); Zagreb
• Defense date and country: 2022-09-02, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology

Abstract

Unatoč napretku medicine zloćudni tumori su i dalje jedan od vodećih zdravstvenih
problema suvremenog doba. Primjena dosadašnjih modaliteta liječenja zloćudnih
tumora i dalje ne polučuje željene ishode u velikom broju slučajeva. Razvojem
znanosti i otkrićem novih tehnologija poput nanotehnologije otvaraju se nove
mogućnosti u terapiji tumora. Nanotehnologija je znanost čije se osnove zasnivaju na
činjenici da čestice u nano-dimenzijama podliježu zakonima kvantne mehanike te
pokazuju drugačija svojstva za razliku od čestica na makroskali. Zahvaljujući
specifičnom ponašanju istih, one dobivaju potencijalno mjesto u dijagnostici i terapiji
zloćudnih tumora, odnosno pokazuju obećavajuće mogućnosti u molekularnoj
dijagnostici, kao kontrastna sredstva u slikovnoj dijagnostici, zatim u isporuci
protutumorskih lijekova na ciljna mjesta u organizmu te u fototermalnoj,
magnetotermalnoj i genskoj terapiji. S obzirom da je nanotehnologija relativno mlado
područje u medicini, mogućnosti primjene nano-čestica u navedenoj disciplini i njihov
utjecaj na biološke sustave nije dovoljno istražen. Osim poznavanja osnova nanočestica
bitno je poznavati i njihovo ponašanje u okviru biološkog sustava kako bi se
mogle primijeniti u svrhe dijagnostike i terapije u ljudi. Cilj ovog rada je dobiti kritički
uvid u nanotehnologiju putem osnova nanotehnologije, njezine raznolike uporabe u
onkologiji, prednosti nanotehnologije te potencijalnih zapreka u primjeni na
pacijentima.

Abstract (english)

Despite the progress of medicine, malignant tumors are still one of the leading health
problems of the modern age. The use of current treatment modalities for malignant
tumors still does not produce the desired results in a large number of cases. The
development of science and the discovery of new technologies such as
nanotechnology open up new possibilities in tumor therapy. Nanotechnology is a
science whose foundations are based on the fact that particles in nano dimensions
are subject to the laws of quantum mechanics and exhibit different properties in
contrast to particles on a macro scale. Thanks to their specific behavior, they have a
potential place in the diagnosis and therapy of malignant tumors, that is, they show
promising possibilities in molecular diagnostics, as contrast agents in imaging
diagnostics, then in the delivery of antitumor drugs to target sites in the body, and in
photothermal, magnetothermal and gene therapy. Given that nanotechnology is a
relatively young field in medicine, the possibilities of applying nanoparticles in the
mentioned discipline and their impact on biological systems have not been sufficiently
explored. In addition to knowing the basics of nanoparticles, it is important to know
their behavior within the biological system so that they can be used for diagnostic and
therapeutic purposes in humans. The aim of this paper is to gain a critical insight into
nanotechnology through the basics of nanotechnology, its diverse use in oncology, the
advantages of nanotechnology and potential obstacles in its application to patients.

• Keywords: nanotehnologija; zloćudni tumori
• Keywords (english): nanotechnology; malignant tumors
• Language: croatian
• URN:NBN: urn:nbn:hr:105:546316
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-09 10:07:39