Maligni tumori temporalne kosti

master's thesis

• Title (english): Temporal bone carcinoma
• Author: Anton Malbašić
• Mentor: Krsto Dawidowsky (mentor)
• Committee member: Srećko Branica (predsjednik povjerenstva)
• Committee member: Mihael Ries (član povjerenstva)
• Committee member: Krsto Dawidowsky (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Othorhinolaryngology and Head and Neck Surgery); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract

Maligni tumori temporalne kosti rijetki su tumori s raznovrsnom simptomatologijom. Najčešće zahvaćaju periaurikularnu kožu i kožu zvukovoda. Najčešći histološki tip tumora je planocelularni karcinom koji ima tendenciju lokalnog i limfogenog širenja u doušnu žlijezdu i vrat. Drugi najčešći histološki tip tumora ove lokalizacije je bazocelularni karcinom, dok su ostali histološki tipovi svojom učestalošću zanemarivi. Dijagnostika malignih tumora temporalne kosti temelji se na detaljnom dermatološkom i neurootološkom pregledu te radiološkim slikovnim tehnikama. Za ove tumore nema općeprihvaćenog sustava klasifikacije, no najčešće se koristi modificirani Pittsburgh sustav klasifikacije iz 2000. godine. Terapija malignih tumora temporalne kosti je, prije svega, kirurška i sastoji se od različito opsežnih resekcija mekog tkiva zvukovoda i temporalne kosti te površinske parotidektomije i disekcije vrata po indikaciji. Nakon operativnog zahvata, ovisno o opsežnosti samoga zahvata, provodi se rekonstrukcija žrtvovanog ličnoga živca i lične muskulature. Kirurškoj terapiji često se pridružuje dokazano blagotvorna adjuvantna radioterapija, a u novijim se istraživanjima i adjuvantna konkomitantna kemoradioterapija ističe kao opcija za bolesnike s uznapredovalim stadijima bolesti. Prognoza ovih tumora uvelike ovisi o stadiju bolesti, a za uznapredovale stadije ona je izrazito loša.

Abstract (english)

Temporal bone carcinomas are rare tumours with a variable presentation. Despite their rarity, they most commonly derive from the periauricular skin and the external auditory canal skin. The most common histological type of these tumours are squamous cell carcinoma, which tend to spread locally and lymphogenically to the parotid gland and the neck. The second most common histological type of tumours affecting this area are basal cell carcinoma, while other types are negligible in frequency. Diagnosis of malignant temporal bone tumours is based on detailed dermatological and neurootological examination and radiological imaging techniques. There is no generally accepted classification system for these tumours, but the modified Pittsburgh classification system from 2000 is most commonly used. The treatment of malignant tumours of the temporal bone is primarily surgical, and it is based on resections of the soft tissue of the external auditory canal and the temporal bone of various extents, as well as frequent superficial parotidectomy and neck dissection, depending on the indication. After the operation, depending on the extent of it, the reconstruction of the sacrificed facial nerve and facial musculature is performed. Surgery is often accompanied by adjuvant radiotherapy, which is proven to be beneficial for the patients' survival. In a recent research, concomitant chemoradiotherapy has also emerged as an option in advanced stages of the disease. The prognosis of these tumours largely depends on the stage of the disease, and for advanced stages it is extremely poor.

• Keywords: temporalna kost; maligni tumori; planocelularni karcinom; kirurška terapija; lični živac
• Keywords (english): temporal bone; carcinoma; squamous cell carcinoma; surgical therapy; facial nerve
• Language: croatian
• URN:NBN: urn:nbn:hr:105:538237
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-19 07:57:13