Von Willebrandov faktor i njegove uloge

master's thesis

• Title (english): Von Willebrand factor and its function
• Author: Mario Mejašić
• Mentor: Ana Boban (mentor)
• Committee member: Robert Likić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Ana Boban (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Von Willebrandov faktor (vWF) je multimerni glikoprotein sintetiziran u megakariocitima i endotelnim stanicama. Njegova najpoznatija uloga je sudjelovanje u primarnoj i sekundarnoj hemostazi. U primarnoj hemostazi omogućuje aktivaciju trombocita na mjestu ozljede krvne žile, a u sekundarnoj djeluje kao nosač koagulacijskog faktora FVIII čime ga stabilizira. Razvojem tehnologije otkrivene su i brojne druge funkcije vWF-a. VWF sudjeluje u regulaciji angiogeneze i rasta glatkih mišićnih stanica krvnih žila te ima ulogu u imunološkom odgovoru gdje sudjeluje u procesu kotrljanja, adhezije i migracije leukocita, te u regulaciji komplementa. Potencijalno važnu ulogu vWF ima u tumorskim stanicama u procesu apoptoze te bi mogao služiti kao biomarker. Kvantitativni ili kvalitativni manjak vWF-a rezultira najčešćim nasljednim poremećajem zgrušavanja krvi, von Willebrandovom bolešću. Simptomi bolesti ovise o vrsti poremećaja u samom vWF-u, a kliničkom slikom dominiraju mukokutana krvarenja. Poremećaj regulacije aktivnosti VWF-a uzrokovat će trombotičnu trombocitopeničnu purpuru i sindrom stečenog von Willebrandovog sindroma. Tijekom pandemije COVID-19 uočava se velik broj tromboembolijskih događaja u kojima značaj vWF-a treba istražiti.

Abstract (english)

Von Willebrand factor is a multimeric glycoprotein synthesized in megakaryocytes and endothelial cells. Its most well-known role is in primary hemostasis where it participates in the aggregation and adhesion of platelets to the site of vascular injury. Another known function of vWF is the carrying and stabilization of factor VIII in plasma. With the development of new technology, numerous additional functions of vWF have been discovered. Participation in the regulation of angiogenesis and growth of vascular smooth muscle cells is also in the domain of vWF. The immune role is manifested in participation in the process of rolling, adhesion and migration of leukocytes and participation in the regulation of complement. VWF has a potentially important role in tumor cells where it plays a role in apoptosis and maight serve as a biomarker. Quantitative or qualitative deficiency of vWF results in the most common inherited blood clotting disorder called von Willebrand disease. The symptoms of the disease depend on the type of the disorder in the vWF itself and are dominated by mucocutaneous bleeding. VWF has a role in trombotic thrombocytopenic purpura and acquired Willebrand syndrome. During the COVID-19 pandemic, a large number of thromboembolic pathologies have been observed, and the importance of vWF in these events should be investigated.

• Keywords: von Willebrandov faktor; trombociti; von Willebrandova bolest; mukokutana krvarenja
• Keywords (english): von Willebrand factor; platelets; von Willebrand disease; mucocutaneous bleeding
• Language: croatian
• URN:NBN: urn:nbn:hr:105:993497
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-20 09:47:15