Udio prijevremenog porođaja uzrokovanog bakterijskim infekcijama u perinatalnom mortalitetu i morbiditetu od 2016. - 2020. na Klinici za ginekologiju i porodništvo Kliničke bolnice Sveti Duh

master's thesis

• Title (english): Proportion of preterm birth caused by bacterial infections in perinatal mortality and morbidity at Gynecology and Obstetrics Clinic, Clinical Hospital Sveti Duh for the 2016-2020 period
• Author: Paola Vrdoljak
• Mentor: Vladimir Blagaić (mentor)
• Committee member: Tatjana Pavelić Turudić (predsjednik povjerenstva)
• Committee member: Željko Duić (član povjerenstva)
• Committee member: Vladimir Blagaić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Prijevremeni porod je svaki porod koji se dogodi prije navršenih 37 tjedana gestacije. Godišnje se oko 15 milijuna djece rodi prijevremeno, dok u Hrvatskoj taj broj iznosi oko 2500 novorođenčadi, tj. oko 6 % živorođenih. Jedan od važnih uzroka prijevremenog poroda su infekcije, posebno bakterijske, koje svojstvenom patogenezom uzrokuju prijevremeno prsnuće vodenjaka prije termina ili intraamnijsku infekciju. Prijevremeni porod predstavlja velik javnozdravstveni problem - uzrok je oko 75 %... More perinatalne smrtnosti i oko dvije trećine neonatalnog morbiditeta. Prijevremeno rođena djeca imaju povećan rizik za različite komplikacije netom nakon rođenja uzrokovane nedovoljnom razvijenošću višestrukih organskih sustava. Također, povećan je rizik i za dugoročne posljedice u vidu neurorazvojnih poremećaja. Cilj ovog retrospektivnog istraživanja provedenog na Klinici za ginekologiju i porodništvo Kliničke bolnice „Sveti Duh“ u razdoblju od 1. siječnja 2016. g. do 31. prosinca 2020. g. bio je detektirati najznačajnije bakterijske uzročnike povezane s prijevremenim porodom te ustanoviti utjecaj na ishod trudnoće, odnosno perinatalni mortalitet i morbiditet. U tom periodu bilo je 13 922 poroda, od kojih je 953 (6,85 %) bilo prijevremenih, a u njih 123 (12,91 %) mikrobiološki je izoliran bakterijski uzročnik u produktima začeća, cerviksu ili kavumu maternice. Najčešće izolirani uzročnici bili su Escherichia coli (16,67 %), Staphilococcus koagulaza neg. (16,67 %), te Enterococcus faecalis (15,48 %). Isti uzročnici gotovo u potpunosti odgovaraju onima detektiranim u (rano) neonatalno umrle novorođenčadi - Escherichia coli (53,05 %), Staphilococcus koagulaza neg. (23,08 %), te Enterococcus faecalis (38,46 %), kao i perinatalno oboljele novorođenčadi. Najčešća oboljenja povezana s infekcijom bila su respiratorni distres sindrom (42,86 %), intrakranijalno krvarenje (20,88 %), konatalna pneumonija (10,99 %), sepsa (9,89 %), prematurna retinopatija (7, 69 %), konjunktivitis (6,59 %) te nekrotizirajući enterokolitis (1,10 %). Less

Abstract (english)

Premature birth is any birth that occurs before 37 weeks of gestation. Annually, about 15 million children are born prematurely, while in Croatia that number is about 2,500 newborns, i.e., about 6% of live births. One of the important causes of premature birth are infections, especially bacterial ones, which, due to their specific pathogenesis, cause preterm premature rupture of membranes or intra-amniotic infection. Premature birth is a major public health problem - it is the cause of... More about 75% of perinatal mortality and about two thirds of neonatal morbidity. Premature children have an increased risk for various short-term complications due to immaturity of multiple organ systems. Also, there is an increased risk for long-term consequences in the form of neurodevelopmental disorders. The aim of this retrospective study conducted at the Gynecology and Obstetrics Clinic, Clinical Hospital "Sveti Duh" in the period from January 1, 2016, to December 31, 2020, was to detect the most significant bacterial pathogens associated with premature birth and to determine the impact on pregnancy outcome, namely perinatal mortality and morbidity. In that period, there were 13,922 births, of which 953 (6.85%) were premature, and in 123 (12.91%) the bacterial pathogen was microbiologically isolated in the products of conception, cervix, or uterine cavity. The most frequently isolated bacteria were Escherichia coli (16.67%), Staphilococcus coagulase neg. (16.67 %), and Enterococcus faecalis (15.48 %). The same pathogens almost completely correspond to those detected in newborns who died in the early neonatal period - Escherichia coli (53.05%), Staphilococcus coagulase neg. (23.08 %), and Enterococcus faecalis (38.46 %), as well as perinatally ill newborns. The most common diseases associated with infection were respiratory distress syndrome (42.86%), intracranial hemorrhage (20.88%), conatal pneumonia (10.99%), sepsis (9.89%), premature retinopathy (7.69%), conjunctivitis (6.59%) and necrotizing enterocolitis (1.10%). Less

• Keywords: prijevremeni porod; bakterijska infekcija; perinatalni morbiditet; perinatalni mortalitet
• Keywords (english): preterm birth; bacterial infection; perinatal morbidity; perinatal mortality
• Language: croatian
• URN:NBN: urn:nbn:hr:105:368461
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-03-24 07:19:31