Značaj preoperativnih vrijednosti koncentracije spermija i ukupnog broja progresivno pokretnih spermija u procjeni uspješnosti varikocelektomije

doctoral thesis

• Author: Pero Bokarica; MBZ: 350940
• Mentor: Ivan Gilja (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2010-05-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

U ovom radu analizirani su podaci dobiveni od 99 bolesnika kojima je učinjena otvorena retroperitonealna varikocelektomija na Zavodu za urologiju Opće bolnice Sveti Duh u periodu od 2001. do 2008. godine. Svim bolesnicima preoperativno i u roku od 6 mjeseci nakon operacije učinjeni su spermiogrami.
Iz spermiograma se promatrala apsolutna i relativna promjena koncentracije spermija, ukupnog broja progresivno pokretnih spermija, koncentracije progresivno pokretnih spermija, postotka progresivno pokretnih spermija, i ukupnog broja spermija u ejakulatu.
Ciljevi rada bili su istražiti da li bolesnici koji preoperativno imaju koncentraciju spermija manju od 10 x 106/ml i/ili ukupan broj progresivno pokretnih spermija manji od 5 x 106 imaju značajniji postoperativni oporavak parametara spermiograma, procijeniti utjecaj otvorene retroperitonealne varikocelektomije na parametre spermiograma i ocijeniti utjecaj dobi u kojoj je učinjena varikocelektomija na oporavak ispitivanih parametara spermiograma.
Rezultat ove studije pokazuje opravdanost učinjene varikocelektomije kod bolesnika koji imaju koncentraciju spermija manju od 10x106/ml i/ili ukupan broj progresivno pokretnih spermija manji od 5X106, jer je kod ovih bolesnika zabilježen značajan postoperativni oporavak spermiograma. Analizirajući sveukupno rezultate svih ispitanika nismo zabilježili statistički značajnu razliku između parametara preoperativnog i postoperativnog spermiograma. Ako iz ispitivane skupine izdvojimo one bolesnike koji su imali postoperativni oporavak spermiograma dobijemo rezultat od 52% uspješnih varikocelektomija.
U našem istraživanju se pokazalo da dob operiranih bolesnika nije utjecala na postoperativni oporavak spermiograma.

Abstract (english)

This study analyzed data obtained from 99 patients who had an open retroperitoneal varicocelectomy at the Department of Urology, General Hospital ʺHoly Spiritʺ over a period from 2001 until 2008. On all patients preoperatively and within 6 months after surgery a seminal analysis was done. We observed absolute and relative changes in the sperm concentration, the total number of progressively moving spermatozoa, the concentration of progressively moving spermatozoa, the percentage of progressively moving spermatozoa, and the total number of sperm in the semen. The goals of this study were to investigate whether patients who preoperatively have a lower sperm concentration of 10 x 106/ml and / or a total number of progressively moving spermatozoa is less than 5 x106 have significant postoperative recovery of seminal parameters. Another goal was to assess the impact of an open retroperitoneal varicocelectomy on the seminal parameters, and also to evaluate the impact of the age in which the varicocelectomy was performed to recovery in the investigated seminal parameters. The result of this study showed the justification of the varicocelectomy in patients who have sperm concentrations of less than 10x106/ml and / or a total number of progressively moving sperm count of less than 5X106, because in these patients we found significant improvement in the seminal parameters. Analyzing the overall results of all subjects we did not record a statistically significant difference between the preoperative and postoperative seminal parameters. When we extracted those patients who had a postoperative recovery in the seminal parameters we recorded a score of 52% successful varicocelectomy. Our research showed that the age of the operated patients did not influence the postoperative recovery of the seminal parameters.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:330244
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 102 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 06:55:53