Povezanost laringofaringealnog refluksa i kroničnog rinosinuitisa

doctoral thesis

• Author: Srđan, Ante Anzić; MBZ: 259974
• Mentor: Tomislav Baudoin (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2011-09-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Kronični rinosinuitis (KRS) je bolest još uvijek nedovoljno razjašnjene
etiologije i nerazjašnjene povezanosti s nekim drugim bolestima.
Hipoteza ovog istraživanja je da postoji povezanost laringofaringealnog
refluksa i kroničnog rinosinuitisa te da se liječenjem laringofaringealnog refluksa
inhibitorima protonske pumpe smanjuju simptomi kroničnog rinosinuitisa. Cilj
istraživanja je bio istražiti povezanost simptoma LPR-a sa simptomima KRS-a,
prije i poslije terapije, istražiti povezanost intenziteta simptoma KRS-a s
rezultatima pH-metrije i utvrditi učinkovitost terapije LPR-a inhibitorima protonske
pumpe (IPP-om) u poboljšanju lokalnog nalaza i subjektivnih simptoma kako
laringofaringitisa tako i kroničnog rinosinuitisa.
Istraživanje je provedeno kao dvostruki slijepi pokus na uzorku od 60
ispitanika, 28 žena i 32 muškarca, sa simptomima LPR-a i dokazanim KRS-om.
Svim ispitanicima prije i nakon završetka studije ocjenjivani su simptomi KRS-a i
LPR-a (reflux simptom index (RSI) i reflux finding score (RFS)), ocjenjivan je
endoskopski nalaz sluznice nosa, histopatološki analizirana sluznica nosa,
rañena analiza eozinofil kationskog proteina (ECP) u ispirku nosne šupljine, te
24-satna pH-metrija. Bolesnici su podijeljeni u dvije skupine, prva je tijekom
sljedećih šezdeset dana uzimala inhibitor protonske pumpe (omeprazol) u dozi
20 mg, dok je kontrolna skupina uzimala placebo.
Terapija inhibitorima protonske pumpe (omeprazol) u dozi 1x20 mg u
trajanju od dva mjeseca statistički značajno pridonosi poboljšanju simptoma
kroničnog rinosinuitisa i endoskopskog nalaza u odnosu na prijeterapijski nalaz.
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Dobiveni rezultati istraživanja govore u prilog hipotezi povezanosti KRS-a i
LPR-a s obzirom na poboljšanja stanja KRS-a nakon liječenja LPR-a inhibitorom
protonske pumpe.

Abstract (english)

Chronic paranasal sinus inflammation is still in the realm of scientific
interest, as its etiology and connection with other respiratory system conditions
has not yet been sufficiently clarified.
The hypothesis of this study is based on the correlation between
laryngopharyngeal reflux (LPR) and chronic paranasal sinus inflammation.
The aim of this study was to ascertain whether treating the
laryngopharyngeal reflux with proton pump inhibitors influences the quality of the
chronic rhinosinusitis treatment.
The research was carried out as a double blind test comprising of 60
participants, 28 women and 32 men with the LPR symptoms and diagnosed
chronic paranasal sinus inflammation. To confirm both diagnoses, all the
participants underwent testing, which included the reflux symptom index (RSI),
reflux finding score (RFS), eosinophil cationic protein analysis of the nasal
lavage fluid, and the 24-hour pH-evaluation using an esophageal sensor
indicating the number and the size of the reflux episodes incidence. The
participants were then divided into two groups. For the next 60 days, the first
group was given proton pump inhibitors (Omeprazole) in 20 mg doses, while
those in the control-group were given placebo doses. The initial testing was
repeated after completion of the therapy.
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The results support the hypothesis claiming the improvement of patient
condition after proton pump inhibitor treatment (Omeprazole) in 20 mg doses a
day during two months’ period in chronic rhinosinusitis.
The study results contribute to our understanding of the connection
between the chronic rhinosinusitis and the laryngopharyngeal reflux, as well as
to the change of the attitudes towards the proton pump inhibitors in treating the
chronic rhinosinusitis.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:176457
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 114 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 07:03:29