Utjecaj medikamentnog liječenja na trajanje opsežnih lokalnih reakcija nakon primjene kombiniranih acelularnih cjepiva protiv pertusisa

doctoral thesis

• Title (english): Effect of medication on the duration of large local reactions following administration of combination acellular pertussis vaccines
• Author: Bernard Kaić; MBZ: 235003
• Mentor: Ira Gjenero-Margan (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2012-06-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Kombinirana cjepiva koja sadrže acelularnu pertusis komponentu u manjeg broja cijepljenih osoba mogu izazvati opsežne lokalne reakcije. Za razliku od cjelostaničnih cjepiva protiv hripavca, kod acelularnih se cjepiva lokalne reakcije češće javljaju nakon docjepljivanja nego u slijedu primarnog cijeljenja, a ponekad mogu biti toliko opsežne da zahvaćaju cijeli ekstremitet. Smatra se da se učestalost kao i težina lokalnih reakcija proporcionalno povećavaju s povećanjem broja ranije primljenih doza acelularnog cjepiva protiv hripavca. Utjecaj sistemne primjene analgetika, antihistaminika i kortikosteroida na trajanje opsežnih lokalnih reakcija nakon cijepljenja ovim cjepivima nije poznat. Ovim istraživanje procijenio sam utjecaja medikamentozne terapije na trajanje opsežnih lokalnih nuspojava nakon primjene kombiniranih cjepiva koja sadrže acelularnu pertusis komponentu. Prema rezultatima ovog istraživanja, primjena medikamentozne terapije (analgetika/antipiretika, sistemnih glukokortikoida ili antihistaminika), ne skraćuje značajno trajanje opsežnih lokalnih reakcija nakon primjene acelularnih cjepiva protiv hripavca, u odnosu na lokalnu primjenu obloga bez medikamentozne terapije.

Abstract (english)

Combined acellular pertussis vaccines can cause large local reactions at injection site. In contrast to whole cell pertussis vaccines, the frequency of large local reactions increases with the number of administered doses of acellular pertussis vaccines. These reactions which occur more often following booster doses, can involve swelling of the entire limb. The effect of analgesics/antipyretics, antihistamines and corticosteroids on the duration of large local reactions at injection site following administration of vaccines has not been systematically studied. The aim of this study was to evaluate the effect of medication on the duration of large local reactions at injection site following administration of combination vaccines containing the acellular pertussis component.
In order to evaluate the effect of medical treatment on duration of large local reactions, I performed a retrospective analysis of reported adverse events, using reported data and additional information collected from vaccination providers.
According to the results of this study, administration of analgesic/antipyretic drugs, corticosteroids and/or antihistamines does not influence the duration of extensive local reactions following administration of acellular pertussis containing vaccines.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:490224
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 57 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 07:18:41