Izraženost transmembranskih receptora tirozin kinaze, faktora proliferacije Ki67 i proteina p53 u planocelularnom karcinomu kože

doctoral thesis

• Title (english): Expression of transmembrane receptors of tyrosine kynase, proliferation marker Ki67 and protein p53 in cutaneous squamous cell carcinoma
• Author: Daniela Ledić Drvar
• Mentor: Zrinka Bukvić Mokos (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2014-09-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Planocelularni karcinom kože (cSCC) drugi je po učestalosti maligni tumor epitela kože i
sluznica. HER signalni putevi igraju važnu ulogu u biologiji nastanka raka, njihova
deregulacija dovodi do rasta i rasapa tumorskih stanica.
Osnovna hipoteza rada bila je: očekuje se veća izraženost transmembranskih receptora tirozin
kinaze (EGFR, HER2 i HER3), biljega Ki67 i proteina p53 u cSCC u odnosu na zdravu
kožu, te u osoba s multiplim tumorima.
Primarni cilj našeg rada bio je usporediti izraženost EGFR, HER2 i HER3, biljega Ki67 i
proteina p53 u cSCC u odnosu na zdravu kožu. Ispitivana skupina je obuhvatila 101
bolesnika kod kojih je utvrđeno 134 planocelularnih karcinoma kože, različitog
patohistološkog stupnja određenog prema Brodersovoj klasifikaciji. Kontrolnu skupinu činila
su 134 uzorka zdrave peritumorske kože istih bolesnika, obrađenih u ispitivanoj skupini.
Rezultati našeg istraživanja pokazali su statistički značajno veću izraženost receptora EGFR,
biljega proliferacije Ki67 i proteina p53 u tumorskoj u odnosu na zdravu kožu, kao i u
multiplim tumorima u odnosu na solitarne. Možemo zaključiti da EGFR, Ki67 i p53 imaju
važnu ulogu u nastanku cSCC, te su povezani s malignijim fenotipom.
Rezultati ovog istraživanja mogli bi imati kliničke implikacije u smislu praktične primjene
inhibitora EGFR u bolesnika s agresivnim oblicima cSCC.

Abstract (english)

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. HER
pathways play a key role in cancer biology, their dysregulation leads to growth and spread of
tumour cells. Main hypothesis of the study was: higher expression of transmembrane
receptors of tyrosine kynase (EGFR, HER2 and HER3), proliferation marker Ki67 and protein
p53 is expected in cSCC compared to normal skin, and in multiple tumours.
Primary objective of our investigation was to compare expression of EGFR, HER2 and
HER3, proliferation marker Ki67 and protein p53 in cSCC and normal skin.
Investigated group included 101 patient with 134 cSCC of different patohistology stage
according to Broders classification. Control group included 134 samples of normal skin of
the same patients analyzed in investigated group.
Results of our investigation showed significantly higher expression of EGFR receptors, Ki67
and protein p53 in tumour compared to normal skin, as well as in multiple compared to solitar
tumours. The above mentioned results led to conclusions that EGFR, Ki67 and p53 have a
key role in cSCC development and that they are related to malignant phenotype. Results of
this study could lead to EGFR inhibitors implementation in treatment of patients with
aggressive cSCC.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:286932
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 106 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 07:23:34