Ultrasonografski biljezi mozga u dijagnozi kongenitalne citomegalovirus infekcije

doctoral thesis

• Title (english): Brain ultrasonographic markers in the diagnosis of congenital cytomegalovirus infection
• Author: Goran Krakar; MBZ: 277103
• Mentor: Vlatka Mejaški Bošnjak (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2014-09-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

UVOD: Dosadašnja istraživanja značenja nalaza lentikulostrijatalne
vaskulopatije (LSV) na intrakranijskoj ultrasonografiji u novorođenčadi u
dijagnozi kongenitalne citomegalovirus infekcije su proturječna. ----- CILJEVI: Ustanoviti dijagnostičku vrijednost ultrazvučnog nalaza biljega
kongenitalne CMV infekcije u populaciji novorođenčadi i dojenčadi sa
neurorazvojnim odstupanjima s LSV-om kao vodećim biljegom. ----- ISPITANICI: U istraživanje je uključeno 234 pacijenta s neurorazvojnim
odstupanjem i s ultrazvučnim nalazom LSV-a, te podijeljeno u dvije skupine
ovisno o dokazanoj ili isključenoj kongenitalnoj CMV infekciji. Uz LSV kao
vodeći, dodatno su evidentirani slijedeći biljezi: periventrikularne fokalne
hiperehogenosti (PFE), paraventrikularna cista, abnormalnosti corpus
callosuma (CC), ventrikulomegalija (LV), periventrikularna difuzna
hieprehogenost (PVE), subependimalna cista, abnormalnosti plexus
choroideusa, prošireni vanjski subarahnoidalni prostori (VSP), abnormalnosti u
građi girusa i sulkusa, hipoplazija malog mozga te prisutnost protoka unutar
LSV-a dopplerom. ----- REZULTATI: pacijenti s kongenitalnom CMV infekcijom na intrakranijskoj
ultrasonografiji uz LSV imaju veći broj pridruženih biljega. Promatranjem svakog
pojedinačnog biljega uz LSV nađena je statistička značajna razlika u učestalosti
nalaza PFE, CC, PVE, VSP i LV u pacijenata s kongenitalnom CMV infekcijom. ----- ZAKLJUČAK: Rezultati ovog istraživanja su pokazali da unatoč tome što LSV
predstavlja nespecifično obilježje može u dojenčadi s neurorazvojnim
odstupanjima služiti kao znak za probir na kongenitalnu CMV infekciju. Kako
raste broj biljega raste i vjerojatnost kongenitalne CMV infekcije, a specifičan
uzorak ne postoji već neki od biljega pokazuju značajnu razliku u učestalosti.

Abstract (english)

INTRODUCTION: Previous research about lenticulostriatal vasculopathy
(LSV) on intracranial ultrasonography in newborns in the diagnosis of congenital
cytomegalovirus infection are contradictory. ----- OBJECTIVES: To determine the diagnostic value of brain ultrasound
markers of congenital CMV infection in newborns and infants with
developmental disorders with LSV as a leading marker. ----- SUBJECTS: The study included 234 patients with neurodevelopmental
disorders and LSV, divided into two groups depending on the confirmed or
excluded congenital CMV infection. With LSV as a leading, additional markers
were recorded as follows: periventricular focal hyperechogenicity (PFE),
paraventricular cysts, corpus callosum abnormalities (CC), ventriculomegalia
(LV), periventricular diffuse hyperechogenicity (PVE), subependimal cysts,
abnormal choroid plexus, wide subarachnoid spaces (VSP), abnormalities of
gyri and sulci, hypoplasia of the cerebellum and the Doppler verified presence
of flow within LSV. ----- RESULTS: Patients with congenital CMV infection with LSV have more of
associated markers in intracranial ultrasonography. Observation of each marker
in association with LSV showed statistically significant difference in the
frequency of PFE, CC, PVE, VSP and LV in patients with congenital CMV
infection. ----- CONCLUSION: The results of this study showed that despite the LSV is a nonspecific
feature, in infants with developmental disorders iz may serve as a sign
for screening for congenital CMV infection. As the number of markers increases
the likelihood of congenital CMV infection rises. There is no specific pattern, but
some of the markers show a significant difference in the frequency.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:035275
• Study programme: Title: Neuroscience; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 99 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 07:23:24