Prognostička vrijednost CT morfoloških karakteristika nemikrocelularnih karcinoma pluća u IA i IB stadiju bolesti

doctoral thesis

• Author: Inja Neralić-Meniga; MBZ: 303346
• Mentor: Mirjana Kujundžić-Tiljak (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2007-03-30, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

CILJ: Cilj ovoga istraživanja bio je utvrditi prognostičku vrijednost predoperacijskih CT morfoloških karakteristika nemikrocelularnih karcinoma pluća (NSCLC) u bolesnika operiranih u IA i IB stadiju bolesti. ISPITANICI I METODE: Ispitivano je 194 bolesnika operiranih u IA i IB stadiju bolesti nemikrocelularnog karcinoma pluća u periodu od 1996. do 2001. godine, svi bolesnici su bili lobektomirani ili pulmektomirani uz disekciju hilarnih i medijastinalnih limfnih čvorova. Pregledane su sve CT snimke i kliničko patološki nalazi. Retrospektivno su analizirani podaci o spolu, dobi, datumu operacije, tipu operativnog zahvata, lokalizaciji tumora, histološkom tipu tumora, stadiju bolesti i datumu smrti. Pregledane su i analizirane sljedeće CT morfološke karakteristike nemikrocelularnog karcinoma pluća: veličina tumora, rubovi tumora, struktura tumora, periferija tumora i odnos tumora s visceralnom pleurom. Kaplan–Meierovom bivarijatnom metodom analizirana je povezanost istraživanih pokazatelja i preživljenja. Primjenom multivarijatnog Coxovog regresijskog modela analizirani su potencijalni prediktori preživljenja. REZULTATI: Bivarijatnom analizom utvrđena je značajna povezanost T stadija, veličine tumora, strukture tumora, periferije tumora i odnosa tumora i visceralne pleure s preživljenjem. Primjenom multivarijatnog Coxovog regresijskog modela kao značajni prediktori izdvojili su se rubovi tumora, periferija tumora i odnos tumora s visceralnom pleurom. ZAKLJUČAK: CT morfološke karakteristike rubova tumora, periferije tumora i odnosa tumora s visceralnom pleurom u IA i IB stadiju bolesti nemikrocelularnog karcinoma pluća su značajni predoperacijski prognostički pokazatelji preživljenja bolesnika nakon operacije.

Abstract (english)

PURPOSE: The aim of this work is to estimate the prognostic value of preoperative chest computed tomography (CT) morphological characteristics in patients resected for non-small cell lung cancer (NSCLC) and classified as stage IA and IB. MATERIALS AND METHODS: 194 patients operated between 1996 and 2001, and classified as stage IA and IB of NSCLC, all patients underwent lobectomy or pulmectomy with hilar and mediastinal lymph node dissection. The chest CT imaging and clinicopathologic records were examined. We retrospectively analyzed sex, age, date of operation, type of resection, location, histology type, stage, and date of death. The chest CT morphological data examined and analyzed were tumor size, tumor margins, tumor structure, periphery of tumor and relation of tumor and visceral pleura. The Kaplan-Meier bivariable method was used to estimate survival. Multivariable method used for predicting survival was Cox proportional hazards regression model. RESULTS: The tumor size, T stage, tumor margins, tumor structure, periphery of tumor and relation tumor to visceral pleura showed significant influence on survival in the bivariable analysis. In the multivariable analysis according Cox model only tumor margins, tumor perphery and tumor relation with visceral pleura entered into regression. CONCLUSION: The CT morphological characteristics of tumor margins, tumor periphery and tumor relation with visceral pleura in IA and IB stage of NSCLC are important preoperative predictive factors for patients outcome after surgery.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:079171
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 131 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 07:51:53