Antagonizacija učinka intramuskularne aplikacije sukcinilkolina u štakora primjenom pentadekapeptida BPC 157

doctoral thesis

• Title (english): Antagonisation of intramuscular application of succinycholine in rats by pentadecapeptide BPC 157
• Author: Vasilije Stambolija; VIAF: 305676214
• Mentor: Predrag Sikirić (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2016-11-22, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Pentadekapeptid BPC 157 pospješuje cijeljenje mišića te pokazuje neuroprotektivna svojstva. Proučili smo antagonizirajuća svojstva BPC 157 na intramuskularnoj aplikaciji sukcinilkolina. Sukcinilkolin je injiciran u desni kvadriceps štakora i proučavan je lokalni paralitički utjecaj u injiciranom mišiću, neposredna kontraktura ekstremiteta, inicijalna agitiranost pred mišičnu blokadu, trzajevi pred kompletni gubitak mišićnog tonusa, bespomično ležanje, bolnu vokalizaciju na lagani dodir te smanjnje mišičnih vlakana i edem u tretiranom i netretiranom kvadricepsu i dijafragmi. BPC 157 je u potpunosti uklonio lokalne učinke sukcinilkolina (kontraktura ekstremiteta) i značajno smanjio ili uklonio bihevioralnu agitiranost, mišične trzajeve i mišičnu blokadu. Kod tretiranih životinja nije bilo bolnih vokalizacija na lagani dodir. BPC 157 je antagonizirao smanjenje broja mišičnih vlakana i edema koje je nastalo u tretiranom i netretiranom kvadricepsu te dijafragmi.

Abstract (english)

Pentadecapeptide BPC 157 improves muscle healing and has neuroprotective properties. We tested BPC 157 counteracting effect on intramuscular application of succinylcholine. Succinylcholine was given into the right quadriceps muscle of the rats, and we assessed local paralytic effect in injected muscle, immediate leg contracture, initial agitation before muscle disability, countless muscle twitches before complete muscle tonus loss, motionless laying, and thereafter, violent screaming upon light touch, and muscle fibers decrease, and edema in injected and non-injected quadriceps muscle and diaphragm. BPC 157 completely eliminated the local succinylcholine effect (leg contracture) and markedly attenuated or eliminated behavioral agitation, muscle twitches, motionless laying. No violent screaming upon light touch appeared in IM succinylcholine-rats. BPC 157 counteracted muscle fibers decrease and edema that otherwise appeared in injected and non-injected quadriceps muscle and diaphragm.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:587731
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 69 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 07:55:31