Analiza refleksa treptaja u oboljelih od multiple skleroze

doctoral thesis

• Title (english): Analysis of the blink reflex in multiple sclerosis patients
• Author: Lidija Dežmalj Grbelja
• Mentor: Demarin Vida (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2018-04-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Multipla skleroza (MS) je kronična autoimuna bolest središnjeg živčanog sustava čije je
osnovno obilježje upala, demijelinizacija i degeneracija aksona. Neurofiziološke metode u
dijagnostici MS su uz magnetsku rezonanciju (MR) neizostavan dio dijagnostičkog algoritma.
Cilj ovog istraživanja bio je ispitati elektrofiziološke karakteristike refleksa treptaja (RT),
usporediti ih s analizom slušnih evociranih potencijala (BAEP) i korelirati s nalazom MR. U
istraživanju je sudjelovalo 60 ispitanika s dijagnozom klinički definitivne MS koji su
podijeljeni u 2 podgrupe: u 19 ispitanika bili su prisutni znaci oštećenja moždanog debla
(MD podgrupa), a 41 ispitanik je bio bez znakova oštećenja moždanog debla (nonMD
podgrupa). Kontrolna skupina je bila sastavljena od 60 zdravih ispitanika, sukladnih po dobi i
spolu. Svim ispitanicima je učinjena analiza RT i analiza BAEP-a, a ispitanicima podgrupe
MD i nonMD su analizirani podaci o prisustvu demijelinizacijskih lezija u moždanom deblu u
nalazu MR. Mjerene su latencije komponenti R1, R2 i R2` RT i IPL III-V latencija u nalazu
BAEP-a te su rezultati pokazali statistički značajnu razliku u vrijednostima svih komponenti
izmjerenim u MD i nonMD skupini u odnosu na kontrolnu skupinu kao i u usporedbi MD i
nonMD skupine. Vrijednosti IPL III-V se nisu razlikovale u MD niti u nonMD skupini u
odnosu na kontrolnu skupinu niti je zabilježena razlika njihovom međusobnom usporedbom.
Statistički značajna razlika je utvrđena u korelaciji produljene R1 komponente s nalazom MR
u obje ispitivane skupine bolesnika. Analiza RT se pokazala kao osjetljivija neurofiziološka
metoda u oboljelih od MS u odnosu na BAEP, neovisno o prisustvu znakova oštećenja
moždanog debla.

Abstract (english)

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterised by inflammation, demyelinisation and axonal degeneration. Neurophysiological
methods are indispensable part of diagnostic algorithm in MS. The aim of this study was to
examine the electrophysiological characteristics of the blink reflex (BR), compare them with
the brainstem auditory evoked potentials (BAEP) and correlate with MRI findings. The study
included 60 subjects with a clinically definitive MS divided into 2 subgroups: 19 subjects
with symptoms of brainstem damage (MD subgroup) and 41 subjects without signs of
brainstem damage (nonMD subgroup). As a control group 60 age and gender matched healthy
subjects were included. Analysis of BR and BAEP was done on all participants. Data of MRI
findings, regarding presence of demyelinating lesion in brainstem were analyzed in MD and
nonMD subgroup. We analized latencies of R1, R2 and R2' of BR and IPL III-V of BAEP.
The results showed statistically significant difference in the values of all components of BR
measured in the MD and nonMD group compared to the control group as well as MD
compared to nonMD group. The values of IPL III-V did not differ in either MD or nonMD
group compared to the control group. Statistically significant difference was found in
correlation of R1 component and MRI finding in both MS groups. Difference in IPL III-V
latencies noted between MD and nonMD group was not statistically significant. BR analysis
has been shown to be a more sensitive neurophysiological method in patients with MS than
BAEP, regardless of the presence of brainstem damage.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:722288
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 71 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 08:08:39