Brzina cerebralnoga protoka u bolesnika s prvom psihotičnom epizodom

doctoral thesis

• Title (english): Velocity of Cerebral Blood Flow in Patients with First Psychotic Episode
• Author: Ivana Kekin
• Mentor: Martina Rojnić Kuzman (mentor)
• Mentor: Branko Malojčić (komentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2018-10-05, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Niz istraživanja pokazuje promijenjenu cerebralnu hemodinamiku u pacijenata
oboljelih od shizofrenije. Cilj našeg istraživanja bio je usporediti promjene brzine
krvnog protoka za vrijeme neurokognitivne aktivacije kod pacijenata s prvom
psihotičnom epizodom i kod zdravih sudionika.
U istraživanje smo uključili 46 pacijenata s prvom psihotičnom epizodom i 41
zdravog sudionika. Učinili smo snimanje brzine krvnog protokau srednjim i prednjim
moždanim arterijama za vrijeme neurokognitivnog testiranja u trajanju od 25 minuta
testovima: Test verbalne fluentnosti, Trial making test B i Stroop test.
Pronašli smo signifikantno nižu brzinu krvnog protoka u lijevoj prednjoj moždanoj
arteriji za vrijeme riješavanja svih neurokognitivnih zadataka u pacijenata s prvom
psihotičnom epizodom. Navedeni pronalazak snižene brzine krvnog protoka za
vrijeme riješavanja neurokognitivnih zadataka upućuje na poremećenu hemodinamiku
u prefrontalnom moždanim regijama te potencijalno objašnjava opservirane
neurokognitivne deficite u pacijenata s prvom psihotičnom epizodom.

Abstract (english)

Changes in cerebral hemodynamics have been reported in schizophrenia and proposed
as underlying the cognitive deficits seen in patients. The objective of our study was to
compare changes of the cerebral blood flow velocity during neurocognitive tasks
between the patients with the first episode of psychosis and healthy controls.
We recruited 46 patients with the first episode of psychosis and 41 control subjects.
Transcranial Doppler ultrasonography monitoring of BFV in both middle cerebral
arteries was recorded during 25-minute long neurocognitive assessment with
Phonemic Verbal Fluency test, Trial Making Test B and Stroop test. Between every
consecutive test resting periods were recorded.
Patients with first episode of psychosis
had significantly lower blood flow velocity in left anterior cerebral artery during
neurocognitive tetsing. Decreased blood flow velocity during the execution of
neurocognitive tasks in patients with first episode of psychosis, compared to control
subjects might indicate impaired hemodynamic function in the prefrontal brain areas,
and possibly provide an explanation of some of the observed neurocognitive deficits
in patients with the first episode of psychosis.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:309272
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 157 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 08:12:09